1.1.1.52: 3alpha-hydroxycholanate dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 3alpha-hydroxycholanate dehydrogenase (NAD+), go to the full flat file.

Reaction

lithocholate
+
NAD+
=
3-oxo-5beta-cholan-24-oate
+
NADH
+
H+

Synonyms

alpha-hydroxy-cholanate dehydrogenase, dehydrogenase, 3alpha-hydroxycholanate

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.52 3alpha-hydroxycholanate dehydrogenase (NAD+)

Substrates Products

Substrates Products on EC 1.1.1.52 - 3alpha-hydroxycholanate dehydrogenase (NAD+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3alpha-hydroxy-5beta-cholanate + NAD+
3-oxo-5beta-cholanate + NADH
show the reaction diagram
3alpha-hydroxy-bis-norcholanic acid + NAD+
3-oxo-bis-norcholanic acid + NADH
show the reaction diagram
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
3alpha-hydroxy-norcholanic acid + NAD+
3-oxo-norcholanic acid + NADH
show the reaction diagram
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
cholic acid + NAD+
7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH
show the reaction diagram
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
dehydrocholic acid + NADH
3-hydroxy-7,12-dihydroxy-5beta-cholan-24-oic acid + NAD+
show the reaction diagram
-
i.e. 3,7,12-trioxocholan-24-oic acid
-
-
r
deoxycholic acid + NAD+
12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
show the reaction diagram
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
additional information
?
-
-
no substrates: androsterone and tetrahydrocortisone, methylation of carboxyl group or reduction to alcohol inactivates
-
-
-