1.1.1.51: 3(or 17)beta-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 3(or 17)beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

testosterone
+
NAD(P)+
=
androstenedione
+
NAD(P)H
+
H+

Synonyms

17 beta-HSD3, 17 beta-hydroxysteroid dehydrogenase, 17-beta-HSD, 17-ketoreductase, 17beta-HSD, 17beta-HSD (type 1), 17beta-HSD (type 3), 17beta-HSD type 2, 17beta-HSD type 3, 17beta-HSD type II, 17beta-HSD-3, 17beta-HSD2, 17beta-HSD3, 17beta-HSD5, 17beta-HSD7_2, 17beta-HSOR, 17beta-hydroxy steroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenases, 17beta-hydroxysteroid dehydrogenases type 2, 17beta-hydroxysteroid oxidoreductase, 17betaHSD2, 3 beta-hydroxysteroid dehydrogenase, 3,17beta-HSD, 3,17beta-hydroxysteroid dehydrogenase, 3-beta HSD, 3beta,17beta-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD (type 1), 3beta-HSD type-I, 3beta-HSD type-II, 3beta-HSD/isomerase, 3beta-hydroxy steroid dehydrogenase, 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase/DELTA5-4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxystroid oxidoreductase, 3beta/17beta-hydroxysteroid dehydrogenase, 3beta17betaHSDH, 3betaHSD, AKR1C3, AKR1C35, aldo keto reductase 1C3, beta-hydroxy steroid dehydrogenase, betahsd, dehydrogenase, 17beta-hydroxy steroid, dehydrogenase, 3beta-hydroxy steroid, dehydrogenase, beta-hydroxy steroid, DELTA5-3beta-HSD, DELTA5-3beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD, HSD17B3, LOC101842245, More, pQ3 beta HSD, steroid 17beta-reductase, type 17beta-HSD, type 2 17beta-HSD, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17-beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.51 - 3(or 17)beta-hydroxysteroid dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.022
(R)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25C, recombinant enzyme
0.025
(S)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25C, recombinant enzyme
0.028
(S)-1-indanol
pH 7.4, 25C, recombinant enzyme
0.022
1-Acenaphthenol
pH 7.4, 25C, recombinant enzyme
0.022
17beta-estradiol
pH 7.4, 25C, recombinant enzyme
0.04
2-Cyclohexen-1-ol
pH 7.4, 25C, recombinant enzyme
0.78
20alpha-dihydroprogesterone
-
pH 7.4, with NAD+ as cofactor
0.056
3beta-hydroxyprogesterone
pH 7.4, 25C, recombinant enzyme
-
0.043
4-androstene-3alpha,17beta-diol
pH 7.4, 25C, recombinant enzyme
0.043
5-androstene-3beta,17beta-diol
pH 7.4, 25C, recombinant enzyme
0.027
5alpha-Androstan-3beta-ol-17-one
pH 7.4, 25C, recombinant enzyme
0.057
5alpha-dihydrotestosterone
pH 7.4, 25C, recombinant enzyme
0.013
5alpha-pregnan-3beta-ol-20-one
pH 7.4, 25C, recombinant enzyme
0.022
5beta-androstan-3beta-ol-17-one
pH 7.4, 25C, recombinant enzyme
0.012
5beta-androstane-3alpha,17beta-diol
pH 7.4, 25C, recombinant enzyme
0.036
5beta-androstane-3beta,17beta-diol
pH 7.4, 25C, recombinant enzyme
0.032
5beta-dihydrotestosterone
pH 7.4, 25C, recombinant enzyme
0.0043
5beta-pregnan-3beta,21-diol-20-one
pH 7.4, 25C, recombinant enzyme
-
0.0028
5beta-Pregnan-3beta-ol-20-one
pH 7.4, 25C, recombinant enzyme
0.018
alpha-3-hydroxyhexobarbital
pH 7.4, 25C, recombinant enzyme
-
0.025
beta-3-hydroxyhexobarbital
pH 7.4, 25C, recombinant enzyme
-
0.022
beta-ionol
pH 7.4, 25C, recombinant enzyme
-
0.025
cis-benzene dihydrodiol
pH 7.4, 25C, recombinant enzyme
0.009
Cyclohexanol
pH 7.4, 25C, recombinant enzyme
0.01
dehydroepiandrosterone
pH 7.4, 25C, recombinant enzyme
2.4
dihydrotestosterone
-
pH 7.4, with NAD+ as cofactor
3.9
estradiol
-
pH 7.4, with NAD+ as cofactor
0.018
farnesol
pH 7.4, 25C, recombinant enzyme
0.023
geraniol
pH 7.4, 25C, recombinant enzyme
0.008
geranylgeraniol
pH 7.4, 25C, recombinant enzyme
0.11 - 4.7
NAD+
0.1 - 0.33
NADH
0.15 - 1.3
NADP+
0.023
nerol
pH 7.4, 25C, recombinant enzyme
0.0078 - 3.4
testosterone
0.033
trans-benzene dihydrodiol
pH 7.4, 25C, recombinant enzyme