1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

6-phosphoglucose dehydrogenase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, PfGluPho, VEG11, Vegetative protein 11, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxy-D-glucose 6-phosphate + NAD(P)+
2-deoxy-D-glucono-1,5-lactone 6-phosphate + NAD(P)H
show the reaction diagram
-
low activity
-
-
?
2-deoxy-D-glucose 6-phosphate + NADP+
2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADPH
show the reaction diagram
2-deoxy-D-glucose-6-phosphate + NADP+
2-deoxy-D-gluconate 6-phosphate + NADPH
show the reaction diagram
-
-
-
-
?
6-phosphonogluconate + NADPH
?
show the reaction diagram
D-galactose 6-phosphate + NAD(P)+
D-galactonate 6-phosphate + NADH
show the reaction diagram
D-glucose + NAD(P)+
D-gluconate + NAD(P)H
show the reaction diagram
-
activity only with dimethylsulfoxide added by 40% (v/v)
-
-
?
D-glucose 6-phosphate + deamino-NADP+
?
show the reaction diagram
D-glucose 6-phosphate + deamino-NADP+
D-glucono-1,5-lactone 6-phosphate + deamino-NADPH
show the reaction diagram
-
-
-
-
?
D-glucose 6-phosphate + H2O + NADP+
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NAD(P)+
D-glucono-1,5-lactone 6-phosphate + NAD(P)H
show the reaction diagram
D-glucose 6-phosphate + NAD+
6-phospho-D-glucono-1,5-lactone + NADH + H+
show the reaction diagram
D-glucose 6-phosphate + NAD+
D-glucono-1,5-lactone 6-phosphate + NADH + H+
show the reaction diagram
D-glucose 6-phosphate + NADP+
6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NADP+
D-gluconate 6-phosphate + NADPH
show the reaction diagram
D-glucose 6-phosphate + NADP+
D-glucono-1,5-lactone 6-phosphate + NADPH
show the reaction diagram
D-glucose 6-phosphate + NADP+
D-glucono-1,5-lactone 6-phosphate + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + NADP+
NADPH + ?
show the reaction diagram
-
assay at pH 7.4
-
-
?
D-glucose 6-phosphate + NADP+ + H2O
D-gluconate 6-phosphate + NADPH + H+
show the reaction diagram
D-glucose 6-phosphate + thio-NAD(P)+
D-glucono-1,5-lactone 6-phosphate + thio-NAD(P)H
show the reaction diagram
-
the thio-cofactors give increased activity compared to the non-thio-cofactors
-
-
?
deoxy-D-glucose 6-phosphate + NADP+
?
show the reaction diagram
-
-
-
-
?
additional information
?
-