1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

6-phosphoglucose dehydrogenase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, PfGluPho, VEG11, Vegetative protein 11, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.007 - 0.009
-
cellular extract
0.025
-
cells grown on a phosphate-deficient medium TRP
0.045
-
cells grown on a phosphate-deficient medium TRP
0.077
-
nephridic enzyme
0.09
-
cells grown on a phosphate-sufficient minimal medium M9
0.098
-
cells grown on a phosphate-sufficient minimal medium M9
0.327
-
hepatic enzyme
0.346
-
crude extract, pH 8.0, 25°C
0.64
-
crude enzyme in optimized culture
1.83
-
purified enzyme
4.64
-
purified enzyme
5.7
-
pH 8.0, temperature not specified in the publication
8.35
-
pH 8.5, 25°C
11.23
purified G6PDH1 upon reduction by reduced DTT
14
-
purified enzyme
15.43
-
purified enzyme
16.24
-
purified enzyme
16.7
-
purified enzyme
20.3
purified G6PDH1
22.2
-
untreated fruits
27.5
-
purified wild-type enzyme
27.69
-
purified kidney cortex enzyme
32
-
purified enzyme, pH and temperature not specified in the publication
33.8
-
25°C, pH 7.8, substrates: D-glucose 6-phosphate and NADP+
36.25
-
purified enzyme, pH 6.0, 25°C
36.3
-
fruits treated with benzo-thiadiaziole-7-carbothioic acid S-methyl ester
44.16
-
purified enzyme
52
-
purified isoenzyme II
53.8
-
purified enzyme
54.1
-
purified enzyme
67.6
-
39°C, pH 7.8, substrates: D-glucose 6-phosphate and NADP+
76
-
purified recombinant enzyme, development of a coupled continuous thermostable assay method, determination at 85°C
100
-
25°C, pH 8.0, high-level glucose-6-phosphate dehydrogenase strain DF82
104
-
25°C, pH 8.0, wild-type strain K-10
135
-
purified recombinant mutant R393E
139.5
purified G6PDH1 upon oxidation by diamide
166
-
purified recombinant mutant R393V
176
-
purified recombinant mutant R393L
178
-
purified recombinant mutant R393G
181
-
purified recombinant mutant R393I
201
-
purified isoenzyme II
210
-
purified isoenzyme I
220
-
purified enzyme
222.8
-
recombinant from Escherichia coli
289.6
purified recombinant His-tagged enzyme, pH 7.5, 25°C
480
-
purified enzyme
745
-
purified enzyme
790
-
purified enzyme
1033
-
cofactor: NADP+, G6PDH-2
1077
-
cofactor: NAD+, G6PDH-2
2890
-
cofactor: NADP+, G6PDH-1
3078
-
cofactor: NAD+, G6PDH-1
additional information