1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

6-phosphoglucose dehydrogenase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, PfGluPho, VEG11, Vegetative protein 11, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
-
(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
-
(2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
-
(2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate
-
-
(4Z)-4-(3-bromobenzylidene)-1-(4-methylphenyl)pyrazolidine-3,5-dione
-
-
(5Z)-1-(4-bromophenyl)-5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
(5Z)-1-(4-ethoxyphenyl)-5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
(5Z)-5-[[5-(2-methyl-4-nitrophenyl)furan-2-yl]methylidene]-1-(3-methylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
reversible, non-competitive inhibition versus NADP+, mixed-type versus D-glucose 6-phosphate
2'-phosphoadenosine 5'-diphosphoribose
-
-
2,3-diphosphoglycerate
-
-
2-[(5Z)-5-(4-hydroxy-3-methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-3-phenylpropanoate
-
-
2-[(E)-(4-nitrocyclohexa-2,4-dien-1-yl)(2-phenylhydrazinylidene)methyl]benzene-1,4-diol
-
non-competitive inhibition versus NADP+, non-competitive or mixed-type versus D-glucose 6-phosphate
2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-5-methyl-4-(3,4,5-trimethoxybenzyl)-2,4-dihydro-3H-pyrazol-3-one
-
irreversible, non-competitive inhibition versus NADP+, mixed-type versus D-glucose 6-phosphate
3-(3,4-dichlorophenyl)-1,1'-dimethyl urea
-
cytosolic isozyme, inhibition by uncoupling of photosynthetic electron transport
3-(4-hydroxyphenyl)-2-(pyridin-3-yl)quinazolin-4(3H)-one
-
irreversible, non-competitive inhibition versus NADP+, mixed-type versus D-glucose 6-phosphate
3-(5-bromopyridin-2-yl)-2-(pyridin-3-yl)quinazolin-4(3H)-one
-
irreversible, non-competitive inhibition versus NADP+, mixed-type versus D-glucose 6-phosphate
3-(5-[(E)-[2-(5-nitropyridin-2-yl)hydrazinylidene]methyl]furan-2-yl)benzoic acid
-
-
4-fluoro-N-(4-hydroxynaphthalen-1-yl)benzenesulfonamide
-
-
4-methyl-3-(propan-2-yloxy)-6H-benzo[c]chromen-6-one
-
non-competitive inhibition versus NADP+, mixed-type versus D-glucose 6-phosphate
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-[[5-(4-methoxy-2-nitrophenyl)furan-2-yl]methylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
reversible, competitive inhibition versus NADP+, mixed-type versus D-glucose 6-phosphate
5alpha-androstan-16-alpha-bromo-3beta-ol-17-one
-
in vitro cell viability assays shows a LD50 of 20 microM for Trypanosoma cruzi epimastigotes
5alpha-Androstan-3beta-ol-17-one
-
uncompetitive inhibitor
5alpha-androsten-16-alpha-bromo-3beta-ol-17-one
-
potent inhibitor, in vitro cell viability assays shows a LD50 of 12 microM for Trypanosoma cruzi epimastigotes
6-amino-NAD+
-
irreversibly inhibits G6PD
6-amino-NADP+
-
irreversibly inhibits G6PD
6-phosphogluconate
-
-
adenosine 5' [beta,gamma-amido] triphosphate
-
-
adenosine 5' [beta-thio] diphosphate
-
-
adenosine 5' [gamma-thio] triphosphate
-
-
amikacin
-
in vitro, noncompetitive
ammonia
-
inhibition in vitro and in vivo at sublethal concentration of 0.0022-0.0055 mM, IC50: 0.0187 mM
amoxicillin
Chalcalburnus tarischii
-
-
beta-naphthoquinone-4-sulfonic acid
-
1 mM, 68% inhibition, G6PDH-1; 1 mM, 81% inhibition, G6PDH-2
Blue dextran
-
-
-
ceftriaxone
-
strongly inhibits
Chymotrypsin
-
-
-
Ciprofloxacin
Chalcalburnus tarischii
-
-
cumene hydroperoxide
-
1% residual activity after treatment with 17 mM cumene hydroperoxide at 50°C and pH 7 for 2 h
cycloheximide
-
-
cypermethrin
-
inhibits G6PD in vitro
D-glucose 6-phosphate
-
-
dehydroandrosterone
-
uncompetitive inhibitor
dehydroepiandrosterone
deltamethrin
-
inhibits G6PD both in vivo and in vitro, significantly inhibits activity after the 48th hour. Among pesticides, it is the most effective one, which is widely used both at homes and in agricultural fields. Deltamethrin inhibits the enzyme at very low doses, particularly in in vivo conditions, indicating that fish in natural and cultural environments are susceptible to this pesticide and that deltamethrin contaminations can be cause high mortality in fish population, which may lead to the increase in food insufficiency for increasing populations and cause disruption of ecological balance. Thus, usage of deltamethrin must be well controlled
epiandrosterone
estrogen
-
-
Fe2+
-
strong competitive inhibition
fructose 6-phosphate
-
-
gentamicin sulfate
-
in vitro, noncompetitive
glucosamine 6-phosphate
glucose
glyceraldehyde 3-phosphate
-
-
glyoxylate
-
-
guanidinium hydrochloride
guanosine hydrochloride
-
the enzyme shows a sharp loss in activity above 0.75 M, but is activated by low concentrations of 0.2 M of GdmCl
hydrogen peroxide
-
inhibitory at 0.25%, at pH 7
isocitrate
-
-
KMnO4
Chalcalburnus tarischii
-
-
lidocaine
-
strongly inhibits
marcaine
-
noncompetitive
meloksikam
-
strongly inhibits
metamizol
MgSO4
-
competitive
Mn2+
-
1 mM, 56% inhibition
N-(4-hydroxynaphthalen-1-yl)-2,5-dimethylbenzenesulfonamide
-
-
NADP+
netilmicin
-
inhibition of wild-type and mutant enzymes 1-3
Nicotine
-
inhibits the enzyme from lung, testis, kidney, stomach, and brain, in concert with vitamin E the enzyme from testis brain and liver is inhibited, tissue-specific inhibition of 12.5-48%, overview, nicotine has no effect on enzyme from muscle, heart, and liver
nidazole
Chalcalburnus tarischii
-
-
oleic acid
-
G6PDH-1 is more susceptible to oleic acid than G6PDH-2
p-chloromercuribenzoate
palmitoyl-CoA
Pb2+
-
noncompetitive inhibition
penicillin G potassium
-
in vitro, noncompetitive
pental sodium
-
noncompetitive
peracetic acid
-
1% residual activity after treatment with 4 mM peracetic acid at 25°C and pH 7 for 15 min
phosphoenol pyruvate
-
25% inhibition at 10 mM
phosphoenolpyruvate
prilocaine
-
strongly inhibits
progesterone
-
-
propoxur
-
inhibits G6PD in vitro
pyridoxal 5'-phosphate
-
-
quartz
-
24 h incubation with quartz particles (80 microg/cm(2)) inhibits G6PD activity by 70%. Inhibition is fully prevented by glutathione. Silica exerts on G6PD an oxidative damage
-
Ribulose 1,5-diphosphate
-
-
RNAi
-
sodium ceftizoxime
-
inhibition of wild-type and mutant enzymes 1-3
sodium cefuroxime
-
inhibition of wild-type and mutant enzymes 1-3
streptomycin
-
inhibition of wild-type and mutant enzyme 3
sulfanilacetamide
Chalcalburnus tarischii
-
-
sulfanilamide
Chalcalburnus tarischii
-
-
suramin
-
77% inhibition at 0.05 mM
tert-butyl hydroperoxide
-
1% residual activity after treatment with 290 mM tert-butyl hydroperoxide at 50°C and pH 7 for 3 h
Thioredoxin f
-
from chloroplasts
-
Tl+
-
201Tl solution and radiation exposure has inhibitory effects on the enzyme activity both in vivo and in vitro
Urea
-
inhibition in vitro and in vivo at sublethal concentration of 0.02-0.05 mM, IC50: 0.0238 mM
Vancomycin
vitamin E
-
in concert with nicotine the enzyme from testis brain and liver is inhibited, while the enzyme from muscle and stomach is activated, overview
additional information
-