1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

6-phosphoglucose dehydrogenase, beta-D-glucose-6-phosphate; NADP oxidoreductase, beta-D-glucose-6-phosphate;NADP oxido-reductase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, P2-G6PDH, PfGluPho, plastidial glucose 6-phosphate dehydrogenase, VEG11, Vegetative protein 11, Zwf, zwf-1, Zwf-2, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Expression

Expression on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme activity decreases in the presence of 80 mM NaCl on day 2
-
enzyme expression is slightly induced by D-glucose
-
high glucose level inhibits G6PD expression
TAp73 protein stimulates the expression of glucose-6-phophate dehydrogenase. Enzyme expression is elevated in various tumors, correlating with the upregulation of TAp73
-
the AMPK signaling pathway as well as the inhibitory p38 MAPK pathway are cooperating to inhibit G6PD expression. Arachidonic acid activates AMP-activated protein kinase in primary rat hepatocytes, and this effect is p38 MAPK-dependent. Activation of AMP-activated protein kinase mimics the inhibition by arachidonic acid of the insulin-mediated induction of G6PD. Overexpression of dominant-negative AMP-activated protein kinase abolishes the effect of arachidonic acid on G6PD expression
-
when highland barley is exposed to UV-B radiation, the enzyme activity decreases
-