1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

6-phosphoglucose dehydrogenase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, PfGluPho, VEG11, Vegetative protein 11, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Cloned

Cloned on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
cytosolic isozyme, DNA sequence determination, expression in Escherichia coli
-
DNA and amino acid sequence determination and analysis, expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
DNA and amino acid sequence determination and analysis, functional expression in Escherichia coli strain BL21 as His-tagged enzyme
-
expressed in Escherichia coli DH5alpha strain from the pASK-G6PDH1 plasmid
expression in Escherichia coli
-
expression in Escherichia coli, His-tagged protein
-
expression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
-
expression of wild-type and mutant enzymes in the G6PD-deficient Escherichia coli strain DF213
-
gene g6pd is localized in the Xq28 region, DNA sequence determination and analysis and expression of wild-type and mutant P409R in Saccharomyces cerevisiae, functional complementation of the yeast enzyme deficient mutant strain ZWF1 by the wild-type and mutant P409R
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gene gpd, expression in Escherichia coli strain BL21(DE3) as His-tagged enzyme
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into vector pET16b and expressed in a G6PDH-deficient Escherichia coli strain. Overexpression in the cytosol of the susceptible tobacco cultivar Xanthi
N-terminally His-tagged recombinant G6PDH expressed in Escherichia coli BL21 transformed with recombinant pET28 plasmid
overexpression in Escherichia coli as His-tagged enzyme
-
overexpression in WEHI7.2 cells
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recombinant expression of His-tagged enzyme in Escherichia coli strain C41
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study of functional complementation of the yeast deletion mutant strain zwf1 by human wild-type and mutant enzymes, construction of a human enzyme mutant library containing all possible single nucleotide missense mutations in the eight-residue glucose 6-phosphate binding peptide of the enzyme
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the two variants G6PD(Plymouth) (G163D) and G6PD(Mahidol) (G163S) are constructed by site-directed mutagenesis and expressed in G6PD-deficient Escherichia coli DF 213 cells
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transient expression of the G6PD5 and G6PD6 fused to a GFP gene, cloned into the SpeI site of pCAMBIA1302. T-DNA insertion lines transformed with cosmid clones containing the regions of G6PD5 and G6PD6 isolated from a genomic cosmid (pBIC20) library
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wild-type and clinical mutants expressed in Escherichia coli
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