1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
+
NADPH
+
H+

Synonyms

6-phosphoglucose dehydrogenase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, PfGluPho, VEG11, Vegetative protein 11, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Activating Compound

Activating Compound on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak activation
5-(3alpha,acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
activates
6-aminohexanoic acid
-
marginally increases the refolding yield in the presence of Arg, and it is unable to replace Arg in promoting a high refolding yield
acetazolamide
-
activates
anhydrotetracyclin
induces expression of mature G6PDH1
-
artesunate
-
induces a 25fold increase in glucose-6-phosphate dehydrogenase activity while there is no significant reduction in the red blood cell count. Critical role for glucose-6-phosphate dehydrogenase in the prevention of oxidative stress and lysis of red blood cells in artesunate-treated rats
butanol
-
marginally increases the refolding yield in the presence of Arg, and it is unable to replace Arg in promoting a high refolding yield
cyclophilin A
-
facilitates refolding, the yield, at about 82%, is about 12% higher than without cyclophilin A. Even with 0.0004 mM cyclophilin A in the standard refolding buffer, maximal recovery takes about 7 days
-
dithiothreitol
-
dithiothreitol has major positive influence on refolding
glucosamine 6-phosphate
-
-
glycerol
-
marginally increases the refolding yield in the presence of Arg, and it is unable to replace Arg in promoting a high refolding yield
guanosine hydrochloride
-
the enzyme shows a sharp loss in activity above 0.75 M, but is activated by low concentrations of 0.2 M of GdmCl
H2O2
-
H2O2, produced under salt stress, induces increased G6PDH activity and the enzymes of glutathione cycle, which concomitantly results in an increased reduced glutathione contents
Insulin
-
stimulates, in pregnant women with types 1 diabetes insulin effect on the enzyme activity is lower than in the control. In the group of pregnant women with type 2 diabetes and gestational diabetes the effect of insulin is decreased as compared to control
-
insulin-like growth factor 1
-
stimulates, in pregnant women with types 1 diabetes effect of insulin-like growth factor 1 is absent. In the group of pregnant women with type 2 diabetes and gestational diabetes the effect of insulin-like growth factor 1 is decreased as compared to control
-
L-Arg
-
L-Arg has major positive influence on refolding. L-Arg is the key player in the refolding of human G6PD, preventing the aggregation of folding intermediate
metamizol
-
activation of mutant enzymes 1 and 2
N-ethylmaleimide
-
blocking the SH group leads to activation of rBmG6PD activity
paraquat
-
activates plastidic isozymes by 10fold by direct action on the enzyme, no activation of the cytosolic isozyme
PEG 3350
-
marginally increases the refolding yield in the presence of Arg, and it is unable to replace Arg in promoting a high refolding yield
-
relaxin
-
stimulates, in pregnant women with types 1 diabetes effect of relaxin is absent. In the group of pregnant women with type 2 diabetes and gestational diabetes the effect of relaxin is somewhat higher as compared to control
-
S-methyl 1,2,3-benzothiadiazole-7-carbothioate
-
treatment of fruits
spermidine
-
activation constant: 0.2 mM
streptomycin
-
activation of mutant enzymes 1 and 2
Sucrose
-
in wild-type seedlings G6PD5 and G6PD6 show small (1.7- and 2fold, respectively) but significant induction by sucrose
trehalose
-
marginally increases the refolding yield in the presence of Arg, and it is unable to replace Arg in promoting a high refolding yield
vitamin E
-
in concert with nicotine the enzyme from testis brain and liver is inhibited, while the enzyme from muscle and stomach is activated by 36% and 20%, respectively, overview
additional information
-