1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

This is an abbreviated version, for detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file.

Reaction

6-phospho-D-gluconate
+
NADP+
=
D-ribulose 5-phosphate
+
CO2
+
NADPH
+
H+

Synonyms

6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, D-gluconate-6-phosphate dehydrogenase, gnd, GND1, GNTZII, LlPDH, Os6PGDH2, phosphogluconic acid dehydrogenase, YpjI

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

KI Value

KI Value on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.198 - 0.784
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
3.14
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
0.274 - 1
1,5-diphospho-D-ribulose
0.122 - 0.5
1,5-diphospho-ribitol
0.0044 - 0.77
2-deoxy-6-phosphono-D-gluconate
0.0015
4-phopho-D-erythronamide
-
pH 7.5, 20C
0.039
4-phospho-D-erythronamide
-
pH 7.5, 20C
0.00013 - 0.011
4-phospho-D-erythronate
0.00001 - 0.0025
4-phospho-D-erythronohydroxamic acid
0.175 - 1.59
4-phospho-D-erythrose
0.0212 - 1
5,6-dideoxy-6-phosphono-D-arabino-hexonate
0.0042
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
0.0878
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
0.007 - 0.433
5-deoxy-5-phosphonoD-arabinonate
0.0056 - 0.0803
5-phospho-D-arabinonamide
0.0034 - 0.109
5-phospho-D-arabinonate
0.0267 - 0.128
5-phospho-D-arabinonhydrazide
0.011 - 0.147
5-phospho-D-arabinono-1,4-lactone
0.0058 - 0.307
5-phospho-D-arabinonohydroxamic acid
0.025 - 0.71
5-phospho-D-arabinose
0.00095 - 0.067
5-phospho-D-ribonate
0.0013 - 0.0358
6-deoxy-6-phosphono-D-gluconate
0.19 - 0.565
6-phospho-D-galactonate
0.135 - 0.8
6-phosphono-D-mannonate
0.109 - 0.192
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
0.00008 - 0.00036
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
287.6
amoxicillin
-
25C, pH 8.0
2.579
cefepime
-
pH 8.0, 25C
130.2
clindamycin
-
25C, pH 8.0
0.77
Imipenem
-
25C, pH 8.0
0.4
lornoxicam
-
25C, pH 8.0
0.57
metronidazole
-
25C, pH 8.0
0.00065 - 0.03191
NADPH
0.939
netilmicin
-
pH 8.0, 25C
42.4
ornidazole
-
25C, pH 8.0
0.588 - 0.714
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
0.000035 - 0.0011
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
65.6
Vancomycin
-
25C, pH 8.0
0.04 - 0.625
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid