1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

This is an abbreviated version, for detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file.

Reaction

6-phospho-D-gluconate
+
NADP+
=
D-ribulose 5-phosphate
+
CO2
+
NADPH
+
H+

Synonyms

6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, D-gluconate-6-phosphate dehydrogenase, gnd, GND1, GNTZII, LlPDH, Os6PGDH2, phosphogluconic acid dehydrogenase, YpjI

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

Inhibitors

Inhibitors on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-catechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epicatechin gallate
-
-
(-)-epigallocatechin
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-epigallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(-)-gallocatechin gallate
-
NADP+-competitive inhibitor of glucose-6-phosphate dehydrogenase
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
-
-
(2R)-(2-hydroxy-3-phosphonooxypropane-1-sulfinyl)acetic acid
(2R)-[3-(bis(benzyloxy)phosphoryloxy)-2-(tetrahydropyran-2-yloxy)propane-1-sulfinyl]acetic acid
(2R,3R)-2,3,4,N-tetrahydroxybutyramide
(3aR,6aR)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4-one
(3R,4R)-3,4-di(tetrahydro-2H-pyranyloxy)tetrahydro-2-furanone
(4R,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid benzyloxyamide
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
i.e. dorzolamide, competitive
(5-(dimethylamine)naphthalin-1-sulfonylchloride)
-
dansyl chloride, DNSCl, rapid inactivation at pH 7.5, 95% inhibition at pH 6.2
1,5-diphospho-D-ribulose
1,5-diphospho-ribitol
2-deoxy-6-phosphono-D-gluconate
2-methyl-5-nitrofuran-3-carboxylic acid
-
-
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
-
-
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
-
-
3-Oxo-2-deoxy-6-phosphogluconate
-
competitive inhibitor
4,5-dichloro-1H-pyrrole-2-carboxylic acid
-
-
4,N-dihydroxy(2R,3R)-2,3-bis(tetrahydropyran-2-yloxy)butyramide
4-chloro-1H-pyrrole-2-carboxylic acid
-
-
4-phospho-D-erythronamide
4-phospho-D-erythronate
4-phospho-D-erythronohydroxamic acid
4-phospho-D-erythrose
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
5,6-dideoxy-6-phosphono-D-arabino-hexonate
5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
weak inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
competitive
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
-
-
5-deoxy-5-phosphonoD-arabinonate
5-phospho-D-arabinonamide
5-phospho-D-arabinonate
5-phospho-D-arabinonhydrazide
5-phospho-D-arabinono-1,4-lactone
5-phospho-D-arabinonohydroxamic acid
5-phospho-D-arabinose
5-phospho-D-ribonate
6-deoxy-6-phosphono-D-gluconate
6-methoxy-7-hydroxycoumarin
-
scopolin
6-phospho-D-allonate
-
-
6-phospho-D-galactonate
6-phosphono-D-mannonate
7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
-
NBD-Cl
acetic acid (1R,2R)-2-acetoxy-1-(acetylbenzyloxyaminocarbonyl)-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (1R,2R)-2-acetoxy-1-benzyloxycarbamoyl-3-(bis(benzyloxy)phosphoryloxy)propyl ester
acetic acid (2R,1R)-2-acetoxy-1-hydroxycarbamoyl-3-phosphonooxypropyl ester
acetyl-CoA
-
-
adenosine
-
-
amikacin
-
in vitro inhibition
amikacin sulfate
-
in vitro and in vivo inhibition
amoxicillin
-
competitive
ampicillin
Butan-2,3-dione
-
-
caffeic acid
-
-
cefepime
ceftazidim
-
in vitro inhibition
Chloramphenicol
-
in vitro inhibition
chlorogenic acid
-
-
Ciprofloxacin
-
in vitro inhibition
citrate
clindamycin
-
competitive
CO2
-
-
D-2-deoxyglucose
D-5-phosphoarabonate
-
-
D-5-phosphoribonate
-
-
D-5-phosphoribosyl-1-diphosphate
D-6-phosphogluconate
-
competitive substrate inhibition at pH 7
D-6-sulfogluconate
D-ATP-ribose
-
-
D-erythrose 4-phosphate
D-fructose 1,6-diphosphate
D-Fructose 1-phosphate
-
-
D-fructose 2,6-bisphosphate
-
-
D-fructose 6-phosphate
D-Glucose 1,6-bisphosphate
D-glucose 6-phosphate
-
-
D-glyceraldehyde 3-phosphate
D-phosphate
-
D-ribulose 5-phosphate
D-xylulose 5-phosphate
-
-
diethyldicarbonate
-
-
diphosphate
esculetin
-
-
ferulic acid
-
-
gentamicin sulfate
-
in vitro inhibition
hexachloroplatinate
-
-
Imipenem
-
noncompetitive
iodoacetamide
isepamycin
-
in vitro inhibition
levofloxacin
-
in vitro inhibition
lornoxicam
-
noncompetitive
metronidazole
-
noncompetitive
Mg2+
-
acts as an inhibitor above 20 mM
N-ethylmaleimide
-
-
NADP+
netilmicin
-
-
netilmicin sulfate
nicotinamide
-
-
ofloxacin
-
in vitro inhibition
ornidazole
-
noncompetitive
oxalate
-
-
oxaloacetate
p-chloromercuribenzoate
p-coumaric acid
-
-
p-hydroxymercuribenzoate
penicillin G
-
in vitro inhibition
perchlorate
-
-
Permanganate
-
-
phosphoenolpyruvate
-
-
phosphoric acid dibenzyl ester (2R,3R)-3-benzyloxycarbamoyl-2,3-dihydroxypropyl ester
phosphoric acid dibenzyl ester (4R,5R)-5-benzyloxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester
phosphoric acid mono-[(4R,5R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl] ester
phosphoric acid mono-[(5R,4R)-5-hydroxycarbamoyl-2,2-dimethyl[1,3]dioxolan-4-ylmethyl] ester
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
-
-
pyridoxal 5'-phosphate
Rose bengal
scopoletin
-
-
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
-
-
sulfate
teicoplanin
-
in vitro inhibition
Tetranitromethane
-
irreversible loss of catalytic activity
Vancomycin
-
competitive
[(2R)-2,3-dihydroxypropylsulfanyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propane-1-sulfinyl]acetic acid benzyl ester
[(2R)-2-acetoxy-3-(bis(benzyloxy)phosphoryloxy)-propylsulfanyl]acetic acid
[(2R)-2-acetoxy-3-phosphonooxypropane-1-sulfinyl]acetic acid
[(4R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethylsulfanyl]acetic acid benzyl ester
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
-
-
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid
[3-(bis(benzyloxy)phosphoryloxy)-(2R)-2-hydroxypropane-1-sulfinyl]acetic acid benzyl ester
additional information
-