1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

This is an abbreviated version, for detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file.

Reaction

6-phospho-D-gluconate
+
NADP+
=
D-ribulose 5-phosphate
+
CO2
+
NADPH
+
H+

Synonyms

6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, D-gluconate-6-phosphate dehydrogenase, gnd, GND1, GNTZII, LlPDH, Os6PGDH2, phosphogluconic acid dehydrogenase, YpjI

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

IC50 Value

IC50 Value on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00128
(-)-catechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00121
(-)-epicatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00072
(-)-epigallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.00145
(-)-gallocatechin gallate
Mus musculus
-
in 0.1 M Tris buffer (pH 7.5), 150 mM NaCl, 6 mM MgCl2, at 30°C
0.0058
(2E)-2-cyano-3-(5-nitrofuran-2-yl)prop-2-enoic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
1.41
(4S)-trans-4-ethylammonio-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Homo sapiens
-
-
0.028
2-methyl-5-nitrofuran-3-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.114
3,3',4,4'-tetramethyl-1H,1'H-2,2'-bipyrrole-5,5'-dicarboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.051
3-methyl-4-oxo-4,7-dihydro-5H-thiopyrano[3,4-b]furan-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.042
4,5-dichloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.043
4-chloro-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.042
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.00253
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.0601
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.045
5-(ethoxycarbonyl)-3,4-dimethyl-1H-pyrrole-2-carboxylic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
287.4
amoxicillin
Homo sapiens
-
25°C, pH 8.0
117.4
clindamycin
Homo sapiens
-
25°C, pH 8.0
0.43
Imipenem
Homo sapiens
-
25°C, pH 8.0
0.17
lornoxicam
Homo sapiens
-
25°C, pH 8.0
0.23
metronidazole
Homo sapiens
-
25°C, pH 8.0
21.79
ornidazole
Homo sapiens
-
25°C, pH 8.0
0.053
potassium 3,4-dioxo-3,4-dihydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
0.073
sodium (4E)-4-(hydroxyimino)-3-oxo-1,2,3,4-tetrahydronaphthalene-1-sulfonate
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication
46.39
Vancomycin
Homo sapiens
-
25°C, pH 8.0
0.056
[(5-nitrofuran-2-yl)methylidene]propanedioic acid
Trypanosoma brucei
-
pH 7.0, temperature not specified in the publication