1.1.1.43: phosphogluconate 2-dehydrogenase

This is an abbreviated version, for detailed information about phosphogluconate 2-dehydrogenase, go to the full flat file.

Reaction

6-phospho-D-gluconate
+
NAD(P)+
=
6-phospho-2-dehydro-D-gluconate
+
NAD(P)H
+
H+

Synonyms

2-keto-6-phosphogluconate reductase, 6-PGADHase, 6-PGDase, 6-PGDH, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (NAD), 6-phosphogluconate-dehydrogenase, 6-phosphogluconic dehydrogenase, 6-phosphoglucuronic acid dehydrogenase, 6PGAD, 6PGD, 6PGDH, gluconate 6-phosphate dehydrogenase, phosphogluconate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.43 phosphogluconate 2-dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.43 - phosphogluconate 2-dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-ketogluconate + NAD(P)H
D-gluconate + NAD(P)+
show the reaction diagram
6-phospho-2-dehydro-D-gluconate + NAD(P)H
6-phospho-D-gluconate + NAD(P)+
show the reaction diagram
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
show the reaction diagram
6-phospho-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+
show the reaction diagram
-
-
-
-
?
6-phospho-D-gluconate + NADP+
6-phospho-2-dehydro-D-gluconate + NADPH + H+
show the reaction diagram
6-phosphono-D-gluconate + NAD(P)+
6-phospho-2-dehydro-D-gluconate + NAD(P)H
show the reaction diagram
-
second step of hexose monophosphate shunt, i.e. HMS
-
-
?
D-glucose-6-phosphate + NAD+
2-dehydro-6-phospho-D-glucose + NADH
show the reaction diagram
D-glucose-6-phosphate + NADP+
2-dehydro-6-phospho-D-glucose + NADPH
show the reaction diagram
-
NADP-specific enzyme, 4% of the activity with 6-phosphogluconate
-
-
?
additional information
?
-