1.1.1.43: phosphogluconate 2-dehydrogenase

This is an abbreviated version, for detailed information about phosphogluconate 2-dehydrogenase, go to the full flat file.

Reaction

6-phospho-D-gluconate
+
NAD(P)+
=
6-phospho-2-dehydro-D-gluconate
+
NAD(P)H
+
H+

Synonyms

2-keto-6-phosphogluconate reductase, 6-PGADHase, 6-PGDase, 6-PGDH, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (NAD), 6-phosphogluconate-dehydrogenase, 6-phosphogluconic dehydrogenase, 6-phosphoglucuronic acid dehydrogenase, 6PGAD, 6PGD, 6PGDH, gluconate 6-phosphate dehydrogenase, phosphogluconate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.43 phosphogluconate 2-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.43 - phosphogluconate 2-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
30 kDa glycoprotein GF-AS
-
significant decrease in enzyme activity in chronic alcohol-treated rats
-
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
-
non-competitive inhibition
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
-
-
Adenosine 5'-triphosphate
-
ATP inhibits the enzyme which is active with NAD+, not the NADP+ dependent activity
dacarbazine
-
non-competitive inhibition
dorzolamide
-
-
fructose 1,6-bisphosphate
Furosemide
-
non-competitive inhibition
gadopentetic acid
-
non-competitive inhibition
guanosine 5'-triphosphate
-
GTP inhibits the NADP+ specific enzyme
ketotifen
-
non-competitive inhibition
meloxicam
-
non-competitive inhibition
methotrexate
-
non-competitive inhibition
metochloropramide
-
non-competitive inhibition
NADPH
additional information
-
not inhibited by 5-(3alpha-hydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3alpha,12alpha-dihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3alpha,acetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, 5-(3,7,12-trioxo-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide, and acetazolamide
-