1.1.1.43: phosphogluconate 2-dehydrogenase

This is an abbreviated version, for detailed information about phosphogluconate 2-dehydrogenase, go to the full flat file.

Reaction

6-phospho-D-gluconate
+
NAD(P)+
=
6-phospho-2-dehydro-D-gluconate
 +
NAD(P)H
 +
H+

Synonyms

2-keto-6-phosphogluconate reductase, 6-PGADHase, 6-PGDase, 6-PGDH, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (NAD), 6-phosphogluconate-dehydrogenase, 6-phosphogluconic dehydrogenase, 6-phosphoglucuronic acid dehydrogenase, 6PGAD, 6PGD, 6PGDH, gluconate 6-phosphate dehydrogenase, phosphogluconate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.43 phosphogluconate 2-dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.43 - phosphogluconate 2-dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3.66
4-[(1R,2S)-1-hydroxy-2-{[2-(4-hydroxyphenyl)ethyl]amino}propyl]phenol
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
0.00253
5-(3alpha,7alpha,12alpha-triacetoxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.0601
5-(3alpha,7alpha,12alpha-trihydroxy-5-beta-cholanamido)-1,3,4-thiadiazole-2-sulfonamide
Homo sapiens
-
-
0.01
dacarbazine
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
1.41
dorzolamide
Homo sapiens
-
-
0.125
Furosemide
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
209
gadopentetic acid
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
0.008
ketotifen
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
0.05
meloxicam
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
0.142
methotrexate
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition
3.27
metochloropramide
Homo sapiens
-
25°C, pH 8.0, non-competitive inhibition