1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Reaction

isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+

Synonyms

AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, ICD, ICD1, ICD2, ICDH, ICDH-1, IDH, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.42 isocitrate dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.003
-
purified recombinant mutant K212Y, forward reaction
0.0046
-
purified chloroplastic isozyme ICDH1
0.065
-
purified recombinant mutant K212Q, forward reaction
0.072
-
mitochondria from green leaves, forward reaction at pH 7.5
0.08
-
purified recombinant mutant Y140E, forward reaction
0.083
-
purified recombinant mutant Y140T, forward reaction
0.102
-
purified recombinant mutant Y140F, forward reaction
0.179
-
purified recombinant mutant Y140K, forward reaction
0.24
-
enzyme extract of cells in stationary growth phase
0.26
-
enzyme extract of cells in growth phase with acid synthesis
0.28
-
purified enzyme, forward reaction
0.3
-
enzyme extract of cells in exponential growth phase
0.44
-
purified recombinant mutant N97D
0.75
-
cell free enzyme extracts of cells grown on glucose, best carbon source
3.16
-
purified recombinant mutant K212R, forward reaction
4.1
-
purified recombinant mutant H315Q
5.29
-
purified recombinant mutant N97A
6.22
-
purified recombinant mutant T78D
7
-
purified recombinant mutant Y316L
7.18
-
purified recombinant mutant S95A
12.7
-
purified recombinant mutant T78A
18.1
-
purified recombinant mutant R314Q
18.5
-
NAD+-linked reaction
20.1
-
purified recombinant mutant H319Q
23
-
NADP+-linked reaction
23.7
Q8X277
purified recombinant enzyme
27.2
-
purified enzyme
33.5
-
-
34.6
-
purified enzyme
36
-
purified recombinant enzyme
37.8
-
purified recombinant wild-type enzyme
38.6
-
purified recombinant wild-type enzyme
38.7
-
purified recombinant mutant K323Q
39.6
-
purified recombinant mutant K321Q
40
-
pH 8.0, 30°C
40.3
-
purified recombinant mutant Y316F
67
purified recombinant N-terminally His6-tagged enzyme, pH and temperature not specified in the publication
75
-
purified enzyme
77.4
-
wild-type liver
108.2
-
transgenic mice liver
162
-
purified recombinant enzyme
219
purified recombinant N-terminally His6-tagged enzyme, pH and temperature not specified in the publication
additional information