1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Reaction

isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+

Synonyms

AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, ICD, ICD1, ICD2, ICDH, ICDH-1, IDH, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.42 isocitrate dehydrogenase (NADP+)

Molecular Weight

Molecular Weight on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30500
-
alpha2, 2 * 30500, SDS-PAGE
42000
-
alpha2, 2 * 42000, SDS-PAGE
43000
-
2 * 43000, recombinant wild-type and mutant enzymes, SDS-PAGE
45400
-
2 * 45400, equilibrium of dimeric and tetrameric species, calculated from sequence; 4 * 45400, equilibrium of dimeric and tetrameric species, calculated from sequence
45837
Q8X277
x * 45837, sequence calculation, x * 60000, recombinant, renatured enzyme, SDS-PAGE
46200
-
2 * 46200, estimated from amino acid sequence
46300
-
x * 46300, SDS-PAGE
46381
-
x * 46381, isozyme IDP1, mass spectrometry, x * 46562, isozyme IDP2, mass spectrometry, x * 47856, isozyme IDP3, mass spectrometry
46562
-
x * 46381, isozyme IDP1, mass spectrometry, x * 46562, isozyme IDP2, mass spectrometry, x * 47856, isozyme IDP3, mass spectrometry
46600
-
2 * 46600, recombinant thrombin cleaved wild-type and mutant enzymes, SDS-PAGE
46705
x * 46705 , sequence calculation
47856
-
x * 46381, isozyme IDP1, mass spectrometry, x * 46562, isozyme IDP2, mass spectrometry, x * 47856, isozyme IDP3, mass spectrometry
47900
-
2 * 47900, calculated from sequence
49000
-
2 * 49000, isoform ICD-1, 2 * 86000, isoform ICD-2, SDS-PAGE. Besides dimers, isoform ICD-1 forms some tetramer, ICD-2 forms trimer; 4 * 49000, isoform ICD-1, SDS-PAGE. Main form is dimer for isoform ICD-1
51000
-
2 * 51000, about, recombinant enzyme, SDS-PAGE
52600
-
2 * 52600
54200
calculated from amino acid sequence
57000
-
alpha2, 2 * 57000, SDS-PAGE
60000 - 70000
-
gel filtration
61000 - 64000
-
ultracentrifugation
62000
-
2 * 62000, SDS-PAGE
64400
-
gel filtration
69100
-
gel filtration
72000
gel filtration
75000 - 80000
81000 - 83000
-
gel filtration
81000
-
gel filtration
82000
-
recombinant mutant Y316F, dynamic light scattering
87000 - 92600
-
gel filtration
90000 - 100000
-
gel filtration
92000
-
recombinant wild-type and mutant enzymes, native PAGE
94000
-
recombinant mutant T78A, native PAGE
95000
Pinus spp.
-
gel filtration
97000
-
recombinant mutant N97D, native PAGE
97900
-
recombinant mutant Y316L, native PAGE at pH 5.5
98000
-
recombinant mutant T78D, native PAGE
99800
-
recombinant wild-type enzyme, native PAGE at pH 5.5
100000
-
gel filtration, main peak, isoform ICD-1
101000
-
recombinant mutant S95A, native PAGE
104000
-
recombinant wild-type enzyme and mutant S95D, native PAGE
105000
107000
-
gel filtration
108000
-
gel filtration
115000
-
gel filtration
117000
-
gel filtration, ICDH1
130000
-
native PAGE
136000
-
gel filtration, ICDH2
174000
-
tetramer, analytical ultracentrifugation
180000
-
gel filtration, isoform ICD-2
200000
-
gel filtration, isoform ICD-1
320000
-
gel filtration, isoform ICD-2
360000
-
gel filtration, high molecular weight form