1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Reaction

isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+

Synonyms

AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, ICD, ICD1, ICD2, ICDH, ICDH-1, IDH, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.42 isocitrate dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2',5'-ADP
-
-
2,3-Butanedione
-
-
2-mercaptoethanol
-
-
2-oxoglutarate
3-morpholinosydnonimine
44% inhibition at 5 mM of leaf and root enzymes
3-phosphoglycerate
-
-
4-hydroxynonenal
-
50% inhibition at 37°C, after 1 h at 0.5 mM, lipid peroxidation product, enzyme becomes susceptible to oxidative damage leading to structural alterations, carbonylation
5'-ADP
adenosine-3',5'-cyclic monophosphate
-
-
cis-aconitate
citrate
Citric acid
-
50% inhibition at 1 mM
desferroxamine
Diamide
-
-
Diethylenetriaminepentaacetic acid
Diphenylchloroarsine
-
-
dithiothreitol
-
-
Fe2+
; the inhibitory effect of the Fe2+ and H2O2 mixture associated with the generation of hydroxyl radicals is lower in enzyme from ischemic heart compared to enzyme from normoxic heart
glutamate
-
80% inhibition of isozyme ICDH2 at 2 mM
glutathione
glutathione disulfide
-
incubation with 5 mM glutathione disulfide for 30 min completely eliminates activity
glyceraldehyde-3-phosphate
-
-
glyoxalate
-
20% inhibition at 1 mM, presence of 1 mM oxaloacetate results in 50% inhibition
glyoxylate
GSH
inhibits the leaf enzyme by 40% at 5 mM, but not the root enzyme
GTP
-
10% inhibition at 1 mM
isocitrate
Itaconate
-
18% inhibition at 5 mM
Li+
-
slight inhibition
lipid hydroperoxide
-
50% inhibition at 37°C, after 1 h at 0.05 mM, lipid peroxidation product, enzyme becomes susceptible to oxidative damage leading to structural alterations, carbonylation
malate
noncompetitive versus NADP+ and isocitrate
Maleate
-
-
malondialdehyde
-
50% inhibition at 37°C, after 1 h at 5 mM, lipid peroxidation product, enzyme becomes susceptible to oxidative damage leading to structural alterations, carbonylation
manganese(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin
monoiodoacetate
N-ethylmaleimide
-
-
NaCl
-
isoform ICD-2, increase in activity in up to 200 mM NaCl. Isoform ICD-1, no influence of NaCl. Above 200 mM, NaCl is inhibitory
NAD+
-
-
NADH
-
noncompetitive
NADP+
NaHCO3
nicotinamide mononucleotide
-
-
oxalate
-
18% inhibition at 5 mM
oxaloacetate
Oxalomalate
oxalylglycine
-
-
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
decarboxylation of isocitrate and oxalosuccinate
peroxynitrite
Phenarsazines
-
-
Phenylglyoxal
-
-
Phenylmercuric nitrate
-
-
phosphoenolpyruvate
propanetricarboxylate
-
-
pyridoxal 5'-phosphate
-
-
Rb+
-
slight inhibition
S-nitrosoglutathione
; 70.5% inhibtion at 5 mM of the leaf enzyme, 37.3% of the root enzyme
Selenite
-
inactivates IDPm
succinate
-
isozymes ICDH2 and ICDH1
Threo-L-Isocitrate
-
-
trans-aconitate
-
isozyme ICDH1, not isozyme ICDH2
Urea
-
low molecular weight form
additional information
-