Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.41: isocitrate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.41

Reaction

isocitrate
+
NAD+
=
2-oxoglutarate
+
CO2
+
NADH
+
H+

Synonyms

At2g17130, At4g35260, At4g35650, At5g03290, AtIDH I, AtIDH II, AtIDH V, AtIDH VI, beta-decarboxylating dehydrogenase, beta-ketoglutaric-isocitric carboxylase, CaIDH, CcIDH, hNAD-IDHalpha, homodimeric NAD+-linked isocitrate dehydrogenase, Icd-2, ICDH, ICDH1, IDH, IDH I, IDH II, IDH III, IDH IV, IDH V, IDH-50, IDH-I, IDH-II, IDH-V, IDH1, IDH2, IDH3, IDH3A, IDH3alpha, IDH5, IDHa, isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitrate dehydrogenase 3alpha subunit, isocitrate-homoisocitrate dehydrogenase, isocitric acid dehydrogenase, isocitric dehydrogenase, McIDH, mIDH, MiIDH, mitochondrial NAD-dependent isocitrate dehydrogenase, monomeric NAD-IDH, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD isocitric dehydrogenase, NAD(P)+-dependent isocitrate dehydrogenase, NAD+-dependent ICDH, NAD+-dependent IDH, NAD+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase 1, NAD+-dependent isocitrate dehydrogenase 3, NAD+-dependent type 1 IDH, NAD+-IDH, NAD+-specific ICDH, NAD+-specific IDH, NAD+-specific isocitrate dehydrogenase, NAD-Dependent IDH, NAD-dependent isocitrate dehydrogenase, NAD-ICDH, NAD-IDH, NAD-isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NADH-IDH, OlIDH, OtIDH, PF0202, PH1722, Rv0066c, threo-DS-isocitrate:NAD+ oxidoreductase (decarboxylating), type 1 isocitrate dehydrogenase, type II homodimeric NAD-IDH, type II NAD+-specific isocitrate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.41 isocitrate dehydrogenase (NAD+)

Specific Activity

Specific Activity on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.084
-
mitochondria from green leaves, forward reaction
0.092
-
partially purified enzyme, idh-II mutant
0.096
-
mitochondria from etiolated leaves, forward reaction
0.15
-
enzyme extract of cells in exponential growth phase
0.16
-
enzyme extract of cells in stationary growth phase
0.169
-
partially purified enzyme, wild-type
0.17
-
enzyme extract of cells in growth phase with acid synthesis
0.2
-
D234C, alpha-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
1.4
-
D230C, alpha-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
120
purified native enzyme
13.5
-
purified recombinant mutant beta-R99Q
14.7
-
with NADP+ as cosubstrate, at pH 8.0, temperature not specified in the publication
2.2
-
purified recombinant mutant gamma-R97Q
2.9
-
-
21.7
-
purified recombinant wild-type enzyme
22.1
-
with NAD+ as cosubstrate, at pH 8.0, temperature not specified in the publication
27 - 31
-
-
29
-
D206N, alpha-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
3.3
-
wild type enzyme, with NADP+ as cosubstrate, at pH 7.5 and 25°C
3.7
-
D215N, gamma-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
3.8
purified recombinant His6-tagged enzyme, pH 7.5, 25°C, with NADP+
49.3
-
wild type enzyme, with NAD+ as cosubstrate, at pH 7.5 and 25°C
50.5
-
with 0.12 mM NADP+ and 2 mM D-isocitrate
53.2
purified recombinant His6-tagged enzyme, pH 7.5, 25°C, with NAD+
6.3
-
with NADP+ as cosubstrate, at pH 8.0 and 25°C
72.3
purified recombinant His6-tagged enzyme, pH 7.5, 25°C, with NAD+
75.5
-
with 0.12 mM NADP+ and 2 mM D-isocitrate
78
-
mutant enzyme D459A/N461A/D463A/F465A, in the presence of Mn2+, at pH 8.0 and 25°C
8.7
purified recombinant His6-tagged enzyme, pH 7.5, 25°C, with NADP+
87.1
-
wild type enzyme, in the presence of Mn2+, at pH 8.0 and 25°C
96.8
-
with NAD+ as cosubstrate, at pH 8.0 and 25°C
additional information
-
no activity on 3-isopropylmalate