1.1.1.41: isocitrate dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about isocitrate dehydrogenase (NAD+), go to the full flat file.

Reaction

isocitrate
+
NAD+
=
2-oxoglutarate
+
CO2
+
NADH

Synonyms

At2g17130, At4g35260, At4g35650, At5g03290, AtIDH I, AtIDH II, AtIDH V, AtIDH VI, beta-decarboxylating dehydrogenase, beta-ketoglutaric-isocitric carboxylase, Icd-2, ICDH, ICDH1, IDH, IDH I, IDH II, IDH III, IDH IV, IDH V, IDH-I, IDH-II, IDH-V, IDH1, IDH2, IDH5, IDHa, isocitrate dehydrogenase, isocitrate dehydrogenase 2, isocitrate-homoisocitrate dehydrogenase, isocitric acid dehydrogenase, isocitric dehydrogenase, McIDH, mIDH, mitochondrial NAD-dependent isocitrate dehydrogenase, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD isocitric dehydrogenase, NAD(P)+-dependent isocitrate dehydrogenase, NAD+-dependent ICDH, NAD+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase 1, NAD+-specific ICDH, NAD+-specific IDH, NAD+-specific isocitrate dehydrogenase, NAD-Dependent IDH, NAD-dependent isocitrate dehydrogenase, NAD-ICDH, NAD-IDH, NAD-isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, PF0202, PH1722, Rv0066c, threo-DS-isocitrate:NAD+ oxidoreductase (decarboxylating)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.41 isocitrate dehydrogenase (NAD+)

Specific Activity

Specific Activity on EC 1.1.1.41 - isocitrate dehydrogenase (NAD+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.084
-
mitochondria from green leaves, forward reaction
0.092
-
partially purified enzyme, idh-II mutant
0.096
-
mitochondria from etiolated leaves, forward reaction
0.15
-
enzyme extract of cells in exponential growth phase
0.16
-
enzyme extract of cells in stationary growth phase
0.169
-
partially purified enzyme, wild-type
0.17
-
enzyme extract of cells in growth phase with acid synthesis
0.2
-
D234C, alpha-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
1.4
-
D230C, alpha-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
2.2
-
purified recombinant mutant gamma-R97Q
2.9
-
-
3.7
-
D215N, gamma-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
13.5
-
purified recombinant mutant beta-R99Q
21.7
-
purified recombinant wild-type enzyme
27 - 31
-
-
29
-
D206N, alpha-subunit mutant, in 20 mM D-isocitrate and 1 mM MnSO4
50.5
-
with 0.12 mM NADP+ and 2 mM D-isocitrate
75.5
-
with 0.12 mM NADP+ and 2 mM D-isocitrate
120
purified native enzyme
additional information
-
no activity on 3-isopropylmalate