1.1.1.4: (R,R)-butanediol dehydrogenase

This is an abbreviated version, for detailed information about (R,R)-butanediol dehydrogenase, go to the full flat file.

Reaction

(R,R)-butane-2,3-diol
+
NAD+
=
(R)-acetoin
+
NADH
+
H+

Synonyms

(2R,3R)-2,3-butanediol dehydrogenase, (R)-2,3-butanediol dehydrogenase, (R)-diacetyl reductase, 1-amino-2-propanol dehydrogenase, 1-amino-2-propanol oxidoreductase, 2,3-BDH/AR, 2,3-butanediol dehydrogenase, 2,3-butanediol dehydrogenase/acetoin reductase, 2R,3R-2,3-BD dehydrogenase, 2R-3R-BDH, acetoin reductase, ADH-9, aminopropanol oxidoreductase, AR/BDH, BDH, BDH1, BDH99::67, BdhA, ButA, butylene glycol dehydrogenase, butyleneglycol dehydrogenase, D-(-)-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, D-2,3-BD dehydrogenase, D-aminopropanol dehydrogenase, dehydrogenase, D-aminopropanol, dehydrogenase, D-butanediol, DHAD, diacetyl reductase (acetoin), EC 1.1.1.74, GDH, GldA, meso-2,3-butanediol dehydrogenase, meso-BDH, NAD(H)-dependent 2,3-butanediol dehydrogenase, NADH-dependent 2,3-butanediol dehydrogenase, R,R-BD-DH, R,R-BDH, SLAC

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.4 (R,R)-butanediol dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.4 - (R,R)-butanediol dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.004
-
with (2S,3s)-butane-2,3-diol as substrate, at pH 7.4 and 30C
0.005
-
with pentane-1,2-diol as substrate, at pH 7.4 and 30C
0.007
-
with butanone as substrate, at pH 7.4 and 30C
0.01
-
with pentane-2,3-dione as substrate, at pH 7.4 and 30C
0.012
-
with hexane-2,5-dione as substrate, at pH 7.4 and 30C
0.019
-
with pentane-2,4-dione as substrate, at pH 7.4 and 30C
0.044
-
with n-butyadehyde as substrate, at pH 7.4 and 30C
0.048
-
with butane-1,2-diol as substrate, at pH 7.4 and 30C
0.084
-
with diacetyl as substrate, at pH 7.4 and 30C
0.093
-
with propane-1,2-diol as substrate, at pH 7.4 and 30C
0.1
wild type enzyme, using 1 mM NADPH as cosubstrate
0.257
-
with 1-hydroxy-2-butanone as substrate, at pH 7.4 and 30C
0.732
-
with 1,3-dihydroxyacetone as substrate, at pH 7.4 and 30C
1.056
-
with (2R,3R)-butane-2,3-diol as substrate, at pH 7.4 and 30C
1.193
-
with (R)-acetoin as substrate, at pH 7.4 and 30C
4.1
mutant enzyme E221S, using 1 mM NADH as cosubstrate
4.65
-
purified native enzyme, pH 7.0, 30C
4.8
mutant enzyme E221S/I222R, using 1 mM NADH as cosubstrate
5.1
-
acetoin, enzyme 1
6.1
mutant enzyme E221S/I222R/A223S, using 1 mM NADH as cosubstrate
7.55
-
acetoin, enzyme 2
13.7
mutant enzyme E221S, using 1 mM NADPH as cosubstrate
35.55
-
diacetyl, enzyme 2
35.6
-
diacetyl, enzyme 1
54.7
mutant enzyme E221S/I222R, using 1 mM NADPH as cosubstrate
92
wild type enzyme, using 1 mM NADH as cosubstrate
93.2
mutant enzyme E221S/I222R/A223S, using 1 mM NADPH as cosubstrate
additional information