1.1.1.4: (R,R)-butanediol dehydrogenase
This is an abbreviated version, for detailed information about (R,R)-butanediol dehydrogenase, go to the full flat file.
Reaction
(R,R)-butane-2,3-diol +
NAD+=
(R)-acetoin +
NADH +
H+
Synonyms
(2R,3R)-2,3-butanediol dehydrogenase, (R)-2,3-butanediol dehydrogenase, (R)-diacetyl reductase, 1-amino-2-propanol dehydrogenase, 1-amino-2-propanol oxidoreductase, 2,3-BDH/AR, 2,3-butanediol dehydrogenase, 2,3-butanediol dehydrogenase/acetoin reductase, 2R,3R-2,3-BD dehydrogenase, 2R-3R-BDH, acetoin reductase, acetoin/diacetyl reductase, ADH-9, aminopropanol oxidoreductase, AR/BDH, BDH, BDH1, BDH99::67, BdhA, ButA, butylene glycol dehydrogenase, butyleneglycol dehydrogenase, D-(-)-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, D-2,3-BD dehydrogenase, D-aminopropanol dehydrogenase, dehydrogenase, D-aminopropanol, dehydrogenase, D-butanediol, DHAD, diacetyl reductase (acetoin), EC 1.1.1.74, GDH, GldA, meso-2,3-butanediol dehydrogenase, meso-BDH, More, NAD(H)-dependent 2,3-butanediol dehydrogenase, NADH-dependent 2,3-butanediol dehydrogenase, R,R-BD-DH, R,R-BDH, SLAC
ECTree
KCat KM Value
KCat KM Value on EC 1.1.1.4 - (R,R)-butanediol dehydrogenase
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0.033
(2R,3R)-2,3-butanediol
-
pH 7.5, 25°C
0.03 - 7.379
(2R,3R)-butane-2,3-diol
221.2
(2S)-acetoin
-
at pH 10.5 and 30°C
187.5
(2S,3S)-butane-2,3-diol
-
at pH 10.5 and 30°C
0.31 - 2.51
(3R,3S)-butane-2,3-diol
-
0.9
(R,R)-butane-2,3-diol
-
at pH 10.5 and 30°C
17
acetaldehyde
-
pH 7.5, 25°C
38
Butanone
-
pH 7.5, 25°C
61.1
diacetyl
at pH 10.0 and 45°C
0.13 - 3.11
meso-butane-2,3-diol
9.875
NAD+
with (2R,3R)-butane-2,3-diol as cosubstrate, at pH 6.5 and 55°C
71.63
NADH
with diacetyl as cosubstrate, at pH 10.0 and 45°C
0.03
(2R,3R)-butane-2,3-diol

-
enzyme DhaD, at pH 9.0 and 30°C; enzyme GldA, at pH 9.0 and 30°C
7.379
(2R,3R)-butane-2,3-diol
at pH 6.5 and 55°C
0.31
(3R,3S)-butane-2,3-diol

-
enzyme DhaD, at pH 9.0 and 30°C
-
2.51
(3R,3S)-butane-2,3-diol
-
enzyme GldA, at pH 9.0 and 30°C
-
0.35
(R)-acetoin

-
mutant S199W, pH 7.5, 25°C
0.48
(R)-acetoin
-
mutant S199G, pH 7.5, 25°C
0.9
(R)-acetoin
-
mutant S199C, pH 7.5, 25°C
1.58
(R)-acetoin
-
at pH 7.0 and 30°C
1.6
(R)-acetoin
-
wild-type, pH 7.5, 25°C
1.9
(R)-acetoin
-
mutant S199A, pH 7.5, 25°C
2.8
(R)-acetoin
-
mutant S199R, pH 7.5, 25°C
7.8
2-butanone

-
mutant S199W, pH 7.5, 25°C
15
2-butanone
-
mutant S199C, pH 7.5, 25°C
17
2-butanone
-
mutant S199G, pH 7.5, 25°C
21
2-butanone
-
wild-type, pH 7.5, 25°C
26
2-butanone
-
mutant S199R, pH 7.5, 25°C
61
2-butanone
-
mutant S199A, pH 7.5, 25°C
0.04
acetoin

-
cosubstrate NADPH, pH 7.0, temperature not specified in the publication
0.4
acetoin
-
cosubstrate NADH, pH 7.0, temperature not specified in the publication
24
acetone

-
mutant S199W, pH 7.5, 25°C
30
acetone
-
mutant S199C, pH 7.5, 25°C
39
acetone
-
mutant S199G, pH 7.5, 25°C
55
acetone
-
wild-type, pH 7.5, 25°C
67
acetone
-
mutant S199A, pH 7.5, 25°C
81
acetone
-
mutant S199R, pH 7.5, 25°C
86
acetone
-
pH 7.5, 25°C
0.11
glycerol

-
enzyme DhaD, at pH 9.0 and 30°C
1.3
glycerol
-
enzyme GldA, at pH 9.0 and 30°C
0.13
meso-butane-2,3-diol

-
enzyme DhaD, at pH 9.0 and 30°C
3.11
meso-butane-2,3-diol
-
enzyme GldA, at pH 9.0 and 30°C
890
NADPH

-
mutant S199R, pH 7.5, 25°C
8900
NADPH
-
mutant S199A, pH 7.5, 25°C
39000
NADPH
-
wild-type, pH 7.5, 25°C