1.1.1.4: (R,R)-butanediol dehydrogenase

This is an abbreviated version, for detailed information about (R,R)-butanediol dehydrogenase, go to the full flat file.

Reaction

Synonyms

(2R,3R)-2,3-butanediol dehydrogenase, (R)-2,3-butanediol dehydrogenase, (R)-diacetyl reductase, 1-amino-2-propanol dehydrogenase, 1-amino-2-propanol oxidoreductase, 2,3-BDH/AR, 2,3-butanediol dehydrogenase, 2,3-butanediol dehydrogenase/acetoin reductase, 2R,3R-2,3-BD dehydrogenase, 2R-3R-BDH, acetoin reductase, acetoin/diacetyl reductase, ADH-9, aminopropanol oxidoreductase, AR/BDH, BDH, BDH1, BDH99::67, BdhA, ButA, butylene glycol dehydrogenase, butyleneglycol dehydrogenase, D-(-)-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, D-2,3-BD dehydrogenase, D-aminopropanol dehydrogenase, dehydrogenase, D-aminopropanol, dehydrogenase, D-butanediol, DHAD, diacetyl reductase (acetoin), EC 1.1.1.74, GDH, GldA, meso-2,3-butanediol dehydrogenase, meso-BDH, More, NAD(H)-dependent 2,3-butanediol dehydrogenase, NADH-dependent 2,3-butanediol dehydrogenase, R,R-BD-DH, R,R-BDH, SLAC

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.4 (R,R)-butanediol dehydrogenase

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Results

in table

1

Activating Compound

363

AA Sequence

3

Application

1

CAS Registry Number

22

Cloned(Commentary)

41

Cofactor

2

Crystallization (Commentary)

14

Engineering

3

Expression

12

General Information

34

Inhibitors

43

KCat/KM [mM/s]

92

KM Value [mM]

21

Metals/Ions

13

Molecular Weight [Da]

45

Natural Substrates/ Products (Substrates)

219

Organism

4

Pathway

28

pH Optimum

3

pH Range

2

pH Stability

1

pI Value

16

Purification (Commentary)

1

Reaction

3

Reaction Type

68

Reference by Title

6

Source Tissue

36

Specific Activity [micromol/min/mg]

2

Storage Stability

221

Substrates and Products (Substrate)

24

Subunits

101

Synonyms

1

Systematic Name

11

Temperature Optimum [°C]

1

Temperature Range [°C]

6

Temperature Stability [°C]

40

Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 1.1.1.4 - (R,R)-butanediol dehydrogenase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.033

(2R,3R)-2,3-butanediol

Clostridium autoethanogenum

-

pH 7.5, 25°C

737501

0.03 - 7.379

(2R,3R)-butane-2,3-diol

2 entries

221.2

(2S)-acetoin

Corynebacterium glutamicum

-

at pH 10.5 and 30°C

737512

187.5

(2S,3S)-butane-2,3-diol

Corynebacterium glutamicum

-

at pH 10.5 and 30°C

737512

0.31 - 2.51

(3R,3S)-butane-2,3-diol

2 entries

-

0.35 - 2.8

(R)-acetoin

7 entries

0.9

(R,R)-butane-2,3-diol

Corynebacterium glutamicum

-

at pH 10.5 and 30°C

737512

7.8 - 61

2-butanone

6 entries

17

acetaldehyde

Clostridium autoethanogenum

-

pH 7.5, 25°C

737501

0.04 - 2

acetoin

3 entries

24 - 86

acetone

7 entries

38

Butanone

Clostridium autoethanogenum

-

pH 7.5, 25°C

737501

61.1

diacetyl

Rhodococcus erythropolis

A0A0E4A9D6

at pH 10.0 and 45°C

739127

0.11 - 1.3

glycerol

2 entries

0.13 - 3.11

meso-butane-2,3-diol

2 entries

9.875

NAD+

Rhodococcus erythropolis

A0A0E4A9D6

with (2R,3R)-butane-2,3-diol as cosubstrate, at pH 6.5 and 55°C

739127

71.63

NADH

Rhodococcus erythropolis

A0A0E4A9D6

with diacetyl as cosubstrate, at pH 10.0 and 45°C

739127

890 - 39000

NADPH

3 entries

0.03

(2R,3R)-butane-2,3-diol

Klebsiella pneumoniae

-

enzyme DhaD, at pH 9.0 and 30°C; enzyme GldA, at pH 9.0 and 30°C

738637

7.379

(2R,3R)-butane-2,3-diol

Rhodococcus erythropolis

A0A0E4A9D6

at pH 6.5 and 55°C

739127

0.31

(3R,3S)-butane-2,3-diol

Klebsiella pneumoniae

-

enzyme DhaD, at pH 9.0 and 30°C

738637

-

2.51

(3R,3S)-butane-2,3-diol

Klebsiella pneumoniae

-

enzyme GldA, at pH 9.0 and 30°C

738637

-

0.35

(R)-acetoin

Clostridium autoethanogenum

-

mutant S199W, pH 7.5, 25°C

739571

0.48

(R)-acetoin

Clostridium autoethanogenum

-

mutant S199G, pH 7.5, 25°C

739571

0.9

(R)-acetoin

Clostridium autoethanogenum

-

mutant S199C, pH 7.5, 25°C

739571

1.58

(R)-acetoin

Corynebacterium glutamicum

-

at pH 7.0 and 30°C

737512

1.6

(R)-acetoin

Clostridium autoethanogenum

-

wild-type, pH 7.5, 25°C

739571

1.9

(R)-acetoin

Clostridium autoethanogenum

-

mutant S199A, pH 7.5, 25°C

739571

2.8

(R)-acetoin

Clostridium autoethanogenum

-

mutant S199R, pH 7.5, 25°C

739571

7.8

2-butanone

Clostridium autoethanogenum

-

mutant S199W, pH 7.5, 25°C

739571

15

2-butanone

Clostridium autoethanogenum

-

mutant S199C, pH 7.5, 25°C

739571

17

2-butanone

Clostridium autoethanogenum

-

mutant S199G, pH 7.5, 25°C

739571

21

2-butanone

Clostridium autoethanogenum

-

wild-type, pH 7.5, 25°C

739571

26

2-butanone

Clostridium autoethanogenum

-

mutant S199R, pH 7.5, 25°C

739571

61

2-butanone

Clostridium autoethanogenum

-

mutant S199A, pH 7.5, 25°C

739571

0.04

acetoin

Escherichia coli

-

cosubstrate NADPH, pH 7.0, temperature not specified in the publication

740952

0.4

acetoin

Escherichia coli

-

cosubstrate NADH, pH 7.0, temperature not specified in the publication

740952

2

acetoin

Clostridium autoethanogenum

-

pH 7.5, 25°C

737501

24

acetone

Clostridium autoethanogenum

-

mutant S199W, pH 7.5, 25°C

739571

30

acetone

Clostridium autoethanogenum

-

mutant S199C, pH 7.5, 25°C

739571

39

acetone

Clostridium autoethanogenum

-

mutant S199G, pH 7.5, 25°C

739571

55

acetone

Clostridium autoethanogenum

-

wild-type, pH 7.5, 25°C

739571

67

acetone

Clostridium autoethanogenum

-

mutant S199A, pH 7.5, 25°C

739571

81

acetone

Clostridium autoethanogenum

-

mutant S199R, pH 7.5, 25°C

739571

86

acetone

Clostridium autoethanogenum

-

pH 7.5, 25°C

737501

0.11

glycerol

Klebsiella pneumoniae

-

enzyme DhaD, at pH 9.0 and 30°C

738637

1.3

glycerol

Klebsiella pneumoniae

-

enzyme GldA, at pH 9.0 and 30°C

738637

0.13

meso-butane-2,3-diol

Klebsiella pneumoniae

-

enzyme DhaD, at pH 9.0 and 30°C

738637

3.11

meso-butane-2,3-diol

Klebsiella pneumoniae

-

enzyme GldA, at pH 9.0 and 30°C

738637

890

NADPH

Clostridium autoethanogenum

-

mutant S199R, pH 7.5, 25°C

739571

8900

NADPH

Clostridium autoethanogenum

-

mutant S199A, pH 7.5, 25°C

739571

39000

NADPH

Clostridium autoethanogenum

-

wild-type, pH 7.5, 25°C

739571

Show Kcat/km Value  (43 entries)