1.1.1.39: malate dehydrogenase (decarboxylating)

This is an abbreviated version, for detailed information about malate dehydrogenase (decarboxylating), go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

AZC3656 protein, dehydrogenase, malate, diphosphate nucleotide dependent malic enzyme, DMA, DME, m-NAD-ME, malic enzyme, malic enzyme 2, malic enzyme-NAD, ME, ME-NAD, ME2, mitochondrial malic enzyme, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD+-dependent malic enzyme, mitochondrial NAD-malic enzyme, NAD(P)+-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent malic enzyme, NAD-malic enzyme, NAD-ME, NAD-ME1, NAD-ME2, NAD-MEH, NAD-preferring malic enzyme, NAD-preferring ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.39 malate dehydrogenase (decarboxylating)

Reference

Reference on EC 1.1.1.39 - malate dehydrogenase (decarboxylating)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Artus, N.N.; Edwards, G.E.
NAD-malic enzyme from plants
FEBS Lett.
182
225-233
1985
Atriplex spongiosa, Brassica oleracea, Crassula argentea, Solanum tuberosum
-
Manually annotated by BRENDA team
Willeford, K.O.; Wedding, R.T.
pH Effects on the activity and regulation of the NAD malic enzyme
Plant Physiol.
84
1084-1087
1987
Solanum tuberosum
Manually annotated by BRENDA team
Willeford, K.O.; Wedding, R.T.
Evidence for a multiple subunit composition of plant NAD malic enzyme
J. Biol. Chem.
262
8423-8429
1987
Crassula argentea, Solanum tuberosum
Manually annotated by BRENDA team
Willeford, K.O.; Wedding, R.T.
Regulation of the NAD malic enzyme from Crassula
Plant Physiol.
80
792-795
1986
Crassula argentea
Manually annotated by BRENDA team
Day, D.A.; Neuburger, M.; Douce, R.
Activation of NAD-linked malic enzyme in intact plant mitochondria by exogenous coenzyme A
Arch. Biochem. Biophys.
231
233-242
1984
Brassica oleracea, Solanum tuberosum
Manually annotated by BRENDA team
Canellas, P.F.; Wedding, R.T.
Kinetic properties of NAD malic enzyme from cauliflower
Arch. Biochem. Biophys.
229
414-425
1984
Brassica oleracea
Manually annotated by BRENDA team
Voegele, R.T.; Mitsch, M.J.; Finan, T.M.
Characterization of two members of a novel malic enzyme class
Biochim. Biophys. Acta
1432
275-285
1999
Sinorhizobium meliloti
Manually annotated by BRENDA team
Wedding, R.T.; Black, M.K.
Physical and kinetic properties and regulation of the NAD malic enzyme purified from leaves of Crassula argentea
Plant Physiol.
72
1021-1028
1983
Crassula argentea
Manually annotated by BRENDA team
Hatch, M.D.; Tsuzuki, M.; Edwards, G.E.
Determination of NAD malic enzyme in leaves of C4 plants
Plant Physiol.
69
483-491
1982
Amaranthus retroflexus
Manually annotated by BRENDA team
Wedding, R.T.; Canellas, P.F.; Black, M.K.
Slow transients in the activity of the NAD malic enzyme from Crassula
Plant Physiol.
68
1416-1423
1981
Crassula argentea
Manually annotated by BRENDA team
Grover, S.D.; Canellas, P.F.; Wedding, R.T.
Purification of NAD malic enzyme from potato and investigation of some physical and kinetic properties
Arch. Biochem. Biophys.
209
396-407
1981
Solanum tuberosum
Manually annotated by BRENDA team
Canellas, P.F.; Wedding, R.T.
Substrate and metal ion interactions in the NAD+ malic enzyme from cauliflower
Arch. Biochem. Biophys.
199
259-264
1980
Brassica oleracea
Manually annotated by BRENDA team
Hoek, H.B.; Pearson, D.J.; Olembo, N.K.
Nicotinamide-adenine dinucleotide-linked malic enzyme in flight muscle of the tse-tse fly (Glossina) and other insects
Biochem. J.
160
253-262
1976
Apis mellifera, Glossina austeni, Glossina longipennis, Glossina morsitans, Glossina pallidipes, Heliocarpus sp., Odontotermes sp., Periplaneta americana, Sarcophaga sp., Schistocerca gregaria, Spodoptera exempta
Manually annotated by BRENDA team
Hatch, M.D.; Mau, S.L.; Kagawa, T.
Properties of leaf NAD malic enzyme from plants with C4 pathway photosynthesis
Arch. Biochem. Biophys.
165
188-200
1974
Amaranthus edulis, Atriplex spongiosa, Panicum miliaceum
Manually annotated by BRENDA team
Mounib, M.S.
NAD- and NADP-malic enzymes in spermatozoa of mammals and fish
FEBS Lett.
48
79-84
1974
Bos taurus, Gadidae, Homo sapiens, salmon
Manually annotated by BRENDA team
Lin, R.C.; Davis, E.J.
Malic enzymes of rabbit heart mitochondria. Separation and comparison of some characteristics of a nicotinamide adenine dinucleotide-preferring and a nicotinamide adenine dinuclweotide phosphate-specific enzyme
J. Biol. Chem.
249
3867-3875
1974
Oryctolagus cuniculus
Manually annotated by BRENDA team
Eyzaguirre, J.; Cornwell, E.; Borie, G.; Ramirez, B.
Two malic enzymes in Pseudomonas aeruginosa
J. Bacteriol.
116
215-221
1973
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Hrdy, I.; Mertens, E.
Purification and partial characterization of malate dehydrogenase (decarboxylating) from Tritrichomonas foetus hydrogenosomes
Parasitology
107
379-385
1993
Tritrichomonas suis
Manually annotated by BRENDA team
Suye, S.; Okada, Y.; Funada, A.; Kawagoe, M.; Inuta, S.
Purification and properties of malic enzyme from Pseudomonas diminuta IFO-13182
J. Ferment. Bioeng.
73
343-347
1992
Brevundimonas diminuta
-
Manually annotated by BRENDA team
Farias de Aragao, M.E.; Jolivet, Y.; Fernandes de Melo, D.; da Guia Silva Lima, M.; Dizengremel, P.
Purification and partial characterization of NAD-dependent malic enzyme isolated from Vigna unguiculata hypocotyls
Plant Physiol. Biochem.
34
363-368
1996
Vigna unguiculata
-
Manually annotated by BRENDA team
Chen, F.; Okabe, Y.; Osano, K.; Tajima, S.
Purification and characterization of an NAD-malic enzyme from Bradyrhizobium japonicum A1017
Appl. Environ. Microbiol.
64
4073-4075
1998
Bradyrhizobium japonicum
Manually annotated by BRENDA team
Liu, D.; Hwang, C.C.; Cook, P.F.
Alternative substrates for malic enzyme: oxidative decarboxylation of L-aspartate
Biochemistry
41
12200-12203
2002
Ascaris suum
Manually annotated by BRENDA team
Coleman, D.E.; Rao, G.S.; Goldsmith, E.J.; Cook, P.F.; Harris, B.G.
Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution
Biochemistry
41
6928-6938
2002
Ascaris suum
Manually annotated by BRENDA team
Karsten, W.E.; Pais, J.E.; Rao, G.S.; Harris, B.G.; Cook, P.F.
Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites
Biochemistry
42
9712-9721
2003
Ascaris suum
Manually annotated by BRENDA team
Rao, G.S.J.; Coleman, D.E.; Karsten, W.E.; Cook, P.F.; Harris, B.G.
Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site
J. Biol. Chem.
278
38051-38058
2003
Ascaris suum
Manually annotated by BRENDA team
Lara, M.V.; Drincovich, M.F.; Andreo, C.S.
Induction of a crassulacean acid-like metabolism in the C(4) succulent plant, Portulaca oleracea L: study of enzymes involved in carbon fixation and carbohydrate metabolism
Plant Cell Physiol.
45
618-626
2004
Portulaca oleracea
Manually annotated by BRENDA team
Kuo, C.W.; Hung, H.C.; Tong, L.; Chang, G.G.
Metal-induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme
Proteins
54
404-411
2004
Homo sapiens
Manually annotated by BRENDA team
Tao, X.; Yang, Z.; Tong, L.
Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism
Structure
11
1141-1150
2003
Homo sapiens
Manually annotated by BRENDA team
Mitsch, M.J.; Cowie, A.; Finan, T.M.
Malic Enzyme Cofactor and Domain Requirements for Symbiotic N2-fixation by Sinorhizobium meliloti
J. Bacteriol.
189
160-168
2006
Sinorhizobium meliloti
Manually annotated by BRENDA team
Karsten, W.E.; Cook, P.F.
Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum
Biochemistry
46
14578-14588
2007
Ascaris suum
Manually annotated by BRENDA team
Aktas, D.F.; Cook, P.F.
Proper positioning of the nicotinamide ring is crucial for the Ascaris suum malic enzyme reaction
Biochemistry
47
2539-2546
2008
Ascaris suum
Manually annotated by BRENDA team
Chang, H.C.; Chen, L.Y.; Lu, Y.H.; Li, M.Y.; Chen, Y.H.; Lin, C.H.; Chang, G.G.
Metal ions stabilize a dimeric molten globule state between the open and closed forms of malic enzyme
Biophys. J.
93
3977-3988
2007
Homo sapiens
Manually annotated by BRENDA team
Ohno, Y.; Nakamori, T.; Zheng, H.; Suye, S.
Reverse reaction of malic enzyme for HCO3- fixation into pyruvic acid to synthesize L-malic acid with enzymatic coenzyme regeneration
Biosci. Biotechnol. Biochem.
72
1278-1282
2008
Brevundimonas diminuta, Brevundimonas diminuta IFO 13182
Manually annotated by BRENDA team
Pongratz, R.L.; Kibbey, R.G.; Shulman, G.I.; Cline, G.W.
Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion
J. Biol. Chem.
282
200-207
2007
Rattus norvegicus
Manually annotated by BRENDA team
Tronconi, M.A.; Fahnenstich, H.; Gerrard Weehler, M.C.; Andreo, C.S.; Fluegge, U.I.; Drincovich, M.F.; Maurino, V.G.
Arabidopsis NAD-malic enzyme functions as a homodimer and heterodimer and has a major impact on nocturnal metabolism
Plant Physiol.
146
1540-1552
2008
Arabidopsis thaliana (Q8L7K9), Arabidopsis thaliana (Q9SIU0)
Manually annotated by BRENDA team
Landete, J.M.; Garcia-Haro, L.; Blasco, A.; Manzanares, P.; Berbegal, C.; Monedero, V.; Zuniga, M.
Requirement of the Lactobacillus casei MaeKR two-component system for L-malic acid utilization via a malic enzyme pathway
Appl. Environ. Microbiol.
76
84-95
2010
Lactobacillus casei, Lactobacillus casei BL23 and ATCC 334
Manually annotated by BRENDA team
Tronconi, M.A.; Gerrard Wheeler, M.C.; Maurino, V.G.; Drincovich, M.F.; Andreo, C.S.
NAD-malic enzymes of Arabidopsis thaliana display distinct kinetic mechanisms that support differences in physiological control
Biochem. J.
430
295-303
2010
Arabidopsis thaliana, Arabidopsis thaliana (Q8L7K9), Arabidopsis thaliana (Q9T0H6)
Manually annotated by BRENDA team
Sato, I.; Yoshikawa, J.; Furusawa, A.; Chiku, K.; Amachi, S.; Fujii, T.
Isolation and properties of malic enzyme and its gene in Rhodopseudomonas palustris No. 7
Biosci. Biotechnol. Biochem.
74
75-81
2010
Rhodopseudomonas palustris (A4F2S6), Rhodopseudomonas palustris No. 7 (A4F2S6)
Manually annotated by BRENDA team
Tronconi, M.A.; Maurino, V.G.; Andreo, C.S.; Drincovich, M.F.
Three different and tissue-specific NAD-malic enzymes generated by alternative subunit association in Arabidopsis thaliana
J. Biol. Chem.
285
11870-11879
2010
Arabidopsis thaliana, Arabidopsis thaliana (Q8L7K9), Arabidopsis thaliana (Q9T0H6)
Manually annotated by BRENDA team
Pongratz, R.L.; Kibbey, R.G.; Cline, G.W.
Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion
Methods Enzymol.
457
425-450
2009
Rattus norvegicus
Manually annotated by BRENDA team
Rzepka, A.; Rut, G.; Krupa, J.
Effect of abiotic stress factors on fluctuations in contents of malate and citrate and on malic enzyme activity in moss gametophores
Photosynthetica
47
141-145
2009
Mnium undulatum, Pilosella officinarum, Polytrichum commune, Polytrichum piliferum
-
Manually annotated by BRENDA team
Ren, J.G.; Seth, P.; Everett, P.; Clish, C.B.; Sukhatme, V.P.
Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2
PLoS ONE
5
e12520
2010
Homo sapiens
Manually annotated by BRENDA team
Zhang, Y.; Aono, T.; Poole, P.; Finan, T.M.
NAD(P)+-malic enzyme mutants of Sinorhizobium sp. strain NGR234, but not Azorhizobium caulinodans ORS571, maintain symbiotic N2 fixation capabilities
Appl. Environ. Microbiol.
78
2803-2812
2012
Azorhizobium caulinodans, Sinorhizobium sp. (B6E9W4), Sinorhizobium sp. NGR234 (B6E9W4)
Manually annotated by BRENDA team
Rodriguez, E.; Navone, L.; Casati, P.; Gramajo, H.
Impact of malic enzymes on antibiotic and triacylglycerol production in Streptomyces coelicolor
Appl. Environ. Microbiol.
78
4571-4579
2012
Streptomyces coelicolor, Streptomyces coelicolor M145
Manually annotated by BRENDA team
Fu, Z.; Zhang, Z.; Liu, Z.; Hu, X.; Xu, P.
The effects of abiotic stresses on the NADP-dependent malic enzyme in the leaves of the hexaploid wheat
Biol. Plant.
55
196-200
2011
Triticum aestivum (A9LIN4), Triticum aestivum Jinmai 47 (A9LIN4)
-
Manually annotated by BRENDA team
Niedzwiecka, N.; Skorkowski, E.F.
Purification and properties of malic enzyme from herring Clupea harengus spermatozoa
Comp. Biochem. Physiol. B
164
216-220
2013
Clupea harengus
Manually annotated by BRENDA team
Hsieh, J.Y.; Chen, M.C.; Hung, H.C.
Determinants of nucleotide-binding selectivity of malic enzyme
PLoS ONE
6
e25312
2011
Ascaris suum
Manually annotated by BRENDA team
Niedzwiecka, N.; Gronczewska, J.; Skorkowski, E.F.
NAD-preferring malic enzyme: localization, regulation and its potential role in herring (Clupea harengus) sperm cells
Fish Physiol. Biochem.
43
351-360
2017
Clupea harengus
Manually annotated by BRENDA team