1.1.1.39: malate dehydrogenase (decarboxylating)

This is an abbreviated version, for detailed information about malate dehydrogenase (decarboxylating), go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

AT2g13560, At4g00570, AZC3656 protein, cytosolic malic enzyme, dehydrogenase, malate, diphosphate nucleotide dependent malic enzyme, DMA, DME, m-NAD-ME, malic enzyme, malic enzyme 2, malic enzyme-NAD, ME, ME-NAD, ME1, ME2, mitochondrial malic enzyme, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD+-dependent malic enzyme, mitochondrial NAD-malic enzyme, NAD(P)+-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent malic enzyme, NAD-dependent malic enzyme 1, NAD-dependent malic enzyme 2, NAD-malate dehydrogenase, NAD-malic enzyme, NAD-ME, NAD-ME1, NAD-ME2, NAD-MEH, NAD-preferring malic enzyme, NAD-preferring ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.39 malate dehydrogenase (decarboxylating)

Disease

Disease on EC 1.1.1.39 - malate dehydrogenase (decarboxylating)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line.
Carcinogenesis
The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.
Carcinoma
Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Carcinoma, Hepatocellular
Activities of enzymes of lipid metabolism in Morris hepatoma 7800 C1 cells.
Purification, kinetic behavior, and regulation of NAD(P)+ malic enzyme of tumor mitochondria.
Carcinoma, Squamous Cell
Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma.
Epilepsy
A Pragmatic Test for Detecting Association between a Dichotomous Trait and the Genotypes of Affected Families, Controls and Independent Cases.
Epilepsy, Generalized
Association analysis of malic enzyme 2 gene polymorphisms with idiopathic generalized epilepsy.
Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy.
Friedreich Ataxia
Cardiac malic enzyme in Friedreich's disease.
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Friedreich's ataxia: malic enzyme activity in cellular fractions of cultured skin fibroblasts.
Friedreich's disease: IV. Reduced mitochondrial malic enzyme activity in heterozygotes.
Mitochondrial malic enzyme in Friedreich's ataxia: failure to demonstrate reduced activity in cultured fibroblasts.
Normal fibroblast mitochondrial malic enzyme activity in Friedreich's ataxia.
Normal mitochondrial malic enzyme levels in Friedreich's ataxia fibroblasts.
Glioma
Effect of hypoxia on the expression of nuclear genes encoding mitochondrial proteins in U87 glioma cells.
The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas.
glucose-6-phosphatase deficiency
Analysis of the albino-locus region of the mouse: IV. Characterization of 34 deficiencies.
Glycogen Storage Disease Type I
Analysis of the albino-locus region of the mouse: IV. Characterization of 34 deficiencies.
Insulinoma
Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.
Leukemia
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Leukemia, Erythroblastic, Acute
Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.
Leukemia, Myeloid, Acute
Enzyme activities of NADPH-forming metabolic pathways in normal and leukemic leukocytes.
Malaria
Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control.
malate dehydrogenase (decarboxylating) deficiency
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Friedreich's ataxia: malic enzyme activity in cellular fractions of cultured skin fibroblasts.
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.
malate dehydrogenase (oxaloacetate-decarboxylating) deficiency
Friedreich ataxia: III. Mitochondrial malic enzyme deficiency.
Melanoma
Metabolic Vulnerability in Melanoma: A ME2 (Me Too) Story.
Neoplasms
Characterization of cytosolic malic enzyme in human tumor cells.
Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line.
Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.
Malic enzyme and malate dehydrogenase activities in rat tracheal epithelial cells during the progression of neoplasia.
Nuclear thyroid hormone receptors, alpha-glycerophosphate dehydrogenases, and malic enzyme in N-nitrosomethylurea-induced rat mammary tumors.
Purification and characterization of the cytosolic NADP(+)-dependent malic enzyme from human breast cancer cell line.
Purification of tumor mitochondrial malic enzyme by specific ligand affinity chromatography.
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.
Pancreatic Neoplasms
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.