1.1.1.39: malate dehydrogenase (decarboxylating)

This is an abbreviated version, for detailed information about malate dehydrogenase (decarboxylating), go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

AZC3656 protein, dehydrogenase, malate, diphosphate nucleotide dependent malic enzyme, DMA, DME, m-NAD-ME, malic enzyme, malic enzyme 2, malic enzyme-NAD, ME, ME-NAD, ME2, mitochondrial malic enzyme, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD+-dependent malic enzyme, mitochondrial NAD-malic enzyme, NAD(P)+-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent malic enzyme, NAD-malic enzyme, NAD-ME, NAD-ME1, NAD-ME2, NAD-MEH, NAD-preferring malic enzyme, NAD-preferring ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.39 malate dehydrogenase (decarboxylating)

Activating Compound

Activating Compound on EC 1.1.1.39 - malate dehydrogenase (decarboxylating)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-N6-etheno-CoA
Crassula argentea
-
activates
2-oxoglutarate
-
-
acetyl-CoA
-
;
adenosine 5'-diphosphoglucose
-
activates
ADP
-
slight stimulstion
alpha-D-glucose 1-phosphate
-
activation
AMP
Crassula argentea
-
competitive activation
aspartate
-
stimulates
ATP
-
slight stimulstion
CoA
-
activation kinetics, overview; activation kinetics, overview
coenzyme A
D-fructose 1,6-bisphosphate
-
-
D-fructose 6-phosphate
-
activation
D-glucose 6-phosphate
-
activation
fructose 1,6-bisphosphate
fumarate
gamma-amino-n-butyrate
-
slight activation
hydroxy-n-butyrate
-
slight activation
Hydroxypyruvate
-
slight activation
L-malate
-
activates in both reaction directions synergistically with fumarate both binding at separate allosteric sites different from the active site, R105 and K143 are involved
oxaloacetate
-
;
phosphoenolpyruvate
SO42-
-
activates
succinate
uridine 5'-diphosphoglucose
-
activates
additional information
-
no activation by CoA and acetyl-CoA, poor activation by ATP and AMP; no activation by oxaloacetate, poor activation by ATP and AMP; poor activation by ATP and AMP
-