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1.1.1.383: ketol-acid reductoisomerase [NAD(P)+]

This is an abbreviated version!
For detailed information about ketol-acid reductoisomerase [NAD(P)+], go to the full flat file.

Reaction

(2R)-2,3-dihydroxy-3-methylbutanoate
+
NAD(P)+
=
(2S)-2-hydroxy-2-methyl-3-oxobutanoate
+
NAD(P)H
+
H+

Synonyms

ilvC, Shewana3_0355

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.383 ketol-acid reductoisomerase [NAD(P)+]

Systematic Name

Systematic Name on EC 1.1.1.383 - ketol-acid reductoisomerase [NAD(P)+]

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SYSTEMATIC NAME
IUBMB Comments
(2R)-2,3-dihydroxy-3-methylbutanoate:NAD(P)+ oxidoreductase (isomerizing)
The enzyme, characterized from the bacteria Hydrogenobaculum sp. and Syntrophomonas wolfei subsp. wolfei and from the archaea Metallosphaera sedula and Ignisphaera aggregans, can use both NADH and NADPH with similar efficiency [cf. EC 1.1.1.86, ketol-acid reductoisomerase (NADP+) and EC 1.1.1.382, ketol-acid reductoisomerase (NAD+)].