1.1.1.378: L-rhamnose 1-dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about L-rhamnose 1-dehydrogenase [NAD(P)+], go to the full flat file.
Reaction
Synonyms
AvLRA1, AvRhaDH, EAT09360, L-rhamnose 1-dehydrogenase, LRA1, NAD(P)+-dependent L-rhamnose-1-dehydrogenase, RhaDH, SpLRA1
ECTree
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Reaction
Reaction on EC 1.1.1.378 - L-rhamnose 1-dehydrogenase [NAD(P)+]
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L-rhamnose + NAD(P)+ = L-rhamnono-1,4-lactone + NAD(P)H + H+
in putative catalytic mechanism, the C1-OH group of L-rhamnose is deprotonated by Tyr159 as a general basic catalyst, with concurrent transfer of the hydride ion to NAD(P)+, and the pKa value of its hydroxyl group is lowered by Lysl63, leading to the stabilization of the tyrosinate anion at physiological pH
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