1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

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For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.375

1.1.1.375

dehydrogenases

methanococcus

jannaschii

l-lactate

nadh-dependent

hyperthermophilic

Reaction

Synonyms

lactate/malate dehydrogenase, LDH-like L-MalDH, MdhII, MJ0409, MJ0490

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

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Results	in table
1	Activating Compound
6	AA Sequence
2	Cloned(Commentary)
13	Cofactor
3	Crystallization (Commentary)
1	Inhibitors
13	KM Value [mM]
5	Metals/Ions
2	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
21	Organism
1	Oxidation Stability
2	Pathway
4	pH Optimum
1	pH Range
4	Purification (Commentary)
1	Reaction
9	Reference
34	Substrates and Products (Substrate)
5	Subunits
16	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

KM Value

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KM Value on EC 1.1.1.375 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

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4.6

(2S)-3-sulfolactate

Methanocaldococcus jannaschii

Q60176

70°C, pH 9.5, cofactor: NADP+

389520

0.025 - 0.15

(S)-malate

2 entries

0.19 - 1.3

3-sulfopyruvate

2 entries

0.14

NADH

Methanocaldococcus jannaschii

Q60176

70°C, pH 8.0

728317

0.02 - 0.2

NADPH

2 entries

0.06 - 0.3

oxaloacetate

3 entries

0.84

pyruvate

2 entries