1.1.1.37: malate dehydrogenase

This is an abbreviated version, for detailed information about malate dehydrogenase, go to the full flat file.

Reaction

(S)-malate
+
NAD+
=
oxaloacetate
+
NADH
+
H+

Synonyms

(R)-2-hydroxyacid dehydrogenase, (S)-malate dehydrogenase, CaMDH, cMDH, cMDH -S, cMDH-L, cyMDH, cytosolic malate dehydrogenase, cytosolic MDH, cytosolic NAD-dependent malate dehydrogenase, halophilic malate dehydrogenase, HmMalDH, L-malate dehydrogenase, L-malate-NAD oxidoreductase, L-malate: NAD oxidoreductase, L-malate: NAD+ oxidoreductase, L-malate:NAD-oxidoreductase, L-MDH, m-MDH, malate (NAD) dehydrogenase, malate dehydrogenase, malate dehydrogenase (NAD), malate dehydrogenase 1, malate dehydrogenase 2, malate: NAD oxidoreductase, MalDH, malic acid dehydrogenase, malic dehydrogenase, mbNAD-MDH, MDH, MDH A, MDH B1, MDH B2, Mdh1, MDH2, Mdh2a, Mdh2b, mitochondrial malate dehydrogenase, mitochondrial MDH, mMDH, mNAD-MDH, More, NAD+-dependent malate dehydrogenase, NAD+-dependent MDH, NAD+-MDH enzymes, NAD-dependent malate dehydrogenase, NAD-dependent malic dehydrogenase, NAD-dependent MDH, NAD-L-malate dehydrogenase, NAD-linked malate dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, NAD-MDH, NAD-specific malate dehydrogenase, Pcal_1699, peroxisomal NAD+-malate dehydrogenase 1, peroxisomal NAD+-malate dehydrogenase 2, PMDH, PMDH1, PMDH2, regulatory subunit of nucleic acid-conducting channel, s-MDH, SrMalDH, TaMDH, VEG69, Vegetative protein 69, YlMdh2p, [LDH-like] MDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.37 malate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.37 - malate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S,3S)-tartrate + NAD+
? + NADH
show the reaction diagram
(S)-2-hydroxyglutarate + NAD+
2-oxoglutarate + NADH + H+
show the reaction diagram
-
oxidized at an extremely slow rate, less than 0.001% of the rate of L-malate oxidation
-
-
r
(S)-malate + 3-acetylpyridine-adenine dinucleotide
oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
show the reaction diagram
-
can also use 3-acetylpyridine-adenine as cofactor
-
-
r
(S)-malate + acetylpyridine adenine dinucleotide
oxaloacetate + reduced acetylpyridine adenine dinucleotide
show the reaction diagram
-
-
-
?
(S)-malate + NAD(P)+
oxaloacetate + NAD(P)H
show the reaction diagram
-
-
-
-
r
(S)-malate + NAD+
acetate + CO2 + H2 + NADH
show the reaction diagram
-
-
-
?
(S)-malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
(S)-malate + NADP+
oxaloacetate + NADPH + H+
show the reaction diagram
1,4,5,6-tetrahydronicotinamide + L-malate
?
show the reaction diagram
-
-
-
-
?
2-oxobutyrate + NADH
2-hydroxybutyrate + NAD+
show the reaction diagram
-
-
-
-
?
2-oxoglutarate + NADH + H+
2-hydroxyglutarate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 6.8 and at pH 8.2
-
-
?
3-acetylpyridine adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
3-bromopyruvate + NADH
3-bromo-2-hydroxypropanoate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 6.8
-
-
?
alpha-keto-malonate + NADH
? + NAD+
show the reaction diagram
alpha-ketoisovalerate + NADH
2-hydroxyisovalerate + NAD+
show the reaction diagram
about 10% of the activity with oxaloacetate at pH 8.2
-
-
?
alpha-ketomalonate + NADH
?
show the reaction diagram
-
-
-
?
citrate + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
hydroxymalonate + NAD+
? + NADH
show the reaction diagram
L-lactate + NAD+
? + NADH
show the reaction diagram
-
cMDH less catalytically efficient than against its natural substrate malate
-
-
?
malate + NAD+
oxaloacetate + NADH
show the reaction diagram
meso-tartrate + NAD+
? + NADH
show the reaction diagram
nicotinamide 1-N6-ethenoadenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
nicotinamide hypoxanthine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
oxaloacetate + NADH
(S)-malate + NAD+
show the reaction diagram
oxaloacetate + NADH
L-malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
(S)-malate + NAD+
show the reaction diagram
oxaloglycolate + NAD+
? + NADH
show the reaction diagram
-
-
-
-
r
p-hydroxyphenylpyruvate + NADH + H+
2-hydroxy-3-(4-hydroxyphenyl)propanoate
show the reaction diagram
-
-
-
?
phenylpyruvate + NADH
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
about 30% of the activity with oxaloacetate at pH 8.2
-
-
?
phenylpyruvate + NADH + H+
2-hydroxy-3-phenylpropanoate + NAD+
show the reaction diagram
-
-
-
?
pyridine 3-aldehyde adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
pyruvate + NAD+
? + NADH
show the reaction diagram
-
cMDH less catalytically efficient than against its natural substrate malate
-
-
?
pyruvate + NADH
2-hydroxypropanoate + NAD+
show the reaction diagram
about 25% of the activity with oxaloacetate at pH 8.2
-
-
?
pyruvate + NADH + H+
(S)-lactate + NAD+
show the reaction diagram
thionicotinamide adenine dinucleotide + L-malate
?
show the reaction diagram
-
-
-
-
?
additional information
?
-