1.1.1.36: acetoacetyl-CoA reductase

This is an abbreviated version, for detailed information about acetoacetyl-CoA reductase, go to the full flat file.

Reaction

(R)-3-hydroxyacyl-CoA
+
NADP+
=
3-oxoacyl-CoA
+
NADPH
+
H+

Synonyms

(3R)-hydroxyacyl-CoA dehydrogenase, (R)-3-hydroxyacyl-CoA dehydrogenase, acetoacetyl CoA reductase, acetoacetyl coenzyme A reductase, acetoacetyl-CoA reductase, beta-ketoacyl reductase, beta-ketoacyl-CoA reductase, beta-ketoacyl-coenzyme A reductase, D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase, D-3-hydroxyacyl-CoA dehydrogenase, D-3-hydroxyacyl-CoA reductase, D-specific 3-hydroxyacyl-CoA dehydrogenase, hydroxyacyl coenzyme-A dehydrogenase, KCR, MFE-2, More, NADP-linked acetoacetyl CoA reductase, NADPH-dependent acetoacetyl-CoA reductase, NADPH-linked acetoacetyl-CoA reductase, NADPH:acetoacetyl-CoA reductase, PHA-specific acetoacetyl-CoA reductase, PhaB, PhbB, polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase, polyhydroxybutyrate enzyme, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.36 acetoacetyl-CoA reductase

Specific Activity

Specific Activity on EC 1.1.1.36 - acetoacetyl-CoA reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.023
-
strain HsMFE-2(Y347A), (3R)-hydroxyacyl-CoA dehydrogenase; strain HsMFE-2(Y410A), (3R)-hydroxyacyl-CoA dehydrogenase
0.039
-
strain HsMFE-2(E408A), (3R)-hydroxyacyl-CoA dehydrogenase
0.041
-
strain HsMFE-2(D490A), (3R)-hydroxyacyl-CoA dehydrogenase
0.046
-
strain HsMFE-2(H406A), (3R)-hydroxyacyl-CoA dehydrogenase
0.047
-
strain HsMFE-2(D370A), (3R)-hydroxyacyl-CoA dehydrogenase
0.048
-
strain HsMFE-2(D517A), (3R)-hydroxyacyl-CoA dehydrogenase
0.051
-
strain HsMFE-2(D510A), (3R)-hydroxyacyl-CoA dehydrogenase
0.056
-
strain HsMFE-2(E366A), (3R)-hydroxyacyl-CoA dehydrogenase
0.066
-
strain HsMFE-2(H532A), (3R)-hydroxyacyl-CoA dehydrogenase
0.08
-
(3R)-hydroxyacyl-CoA dehydrogenase, Hs MFE-2
0.082
-
strain HsMFE-2, (3R)-hydroxyacyl-CoA dehydrogenase
0.091
-
strain UTL-7A, (3R)-hydroxyacyl-CoA dehydrogenase
0.43
-
(R)-3-hydroxybutyryl-CoA as substrate, activity of D-specific 3-hydroxyacyl-CoA dehydrogenase in perMFE-II
0.5
-
(3R)-hydroxyacyl-CoA dehydrogenase, Sc A-/B+
0.53 - 0.62
-
recombinant enzyme in transformed Escherichia coli strain DH5alpha
0.58
-
(R)-3-hydroxydecanoyl-CoA as substrate, activity of D-specific 3-hydroxyacyl-CoA dehydrogenase in perMFE-II
0.9
-
(3R)-hydroxyacyl-CoA dehydrogenase, Sc B-/A+
1.23
-
enzyme from recombinant strain, monitored at 340 nm by the depletion of NADPH during the reaction.
1.3
-
(3R)-hydroxyacyl-CoA dehydrogenase, Sc MFE-2
7.7
-
NADPH-linked
9
-
beta-ketopalmitoyl-CoA
45.2
-
acetoacetyl-CoA
87.9
Pigeon
-
fed pigeons livers
125
-
last purification step, 5.9fold purification. Candida tropicalis recombinant (3R)-hydroxyacyl-CoA dehydrogenase [CiMFE-2(h2delta)] from Escherichia coli
170.1
Pigeon
-
fasted pigeons livers
250
Pigeon
-
-
771
-
NADH-linked, 345 with NADPH
additional information