1.1.1.36: acetoacetyl-CoA reductase

This is an abbreviated version, for detailed information about acetoacetyl-CoA reductase, go to the full flat file.

Reaction

(R)-3-hydroxyacyl-CoA
+
NADP+
=
3-oxoacyl-CoA
+
NADPH
+
H+

Synonyms

(3R)-hydroxyacyl-CoA dehydrogenase, (R)-3-hydroxyacyl-CoA dehydrogenase, acetoacetyl CoA reductase, acetoacetyl coenzyme A reductase, acetoacetyl-CoA reductase, beta-ketoacyl reductase, beta-ketoacyl-CoA reductase, beta-ketoacyl-coenzyme A reductase, D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase, D-3-hydroxyacyl-CoA dehydrogenase, D-3-hydroxyacyl-CoA reductase, D-specific 3-hydroxyacyl-CoA dehydrogenase, hydroxyacyl coenzyme-A dehydrogenase, KCR, MFE-2, More, NADP-linked acetoacetyl CoA reductase, NADPH-dependent acetoacetyl-CoA reductase, NADPH-linked acetoacetyl-CoA reductase, NADPH:acetoacetyl-CoA reductase, PHA-specific acetoacetyl-CoA reductase, PhaB, PhbB, polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase, polyhydroxybutyrate enzyme, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.36 acetoacetyl-CoA reductase

KM Value

KM Value on EC 1.1.1.36 - acetoacetyl-CoA reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0054 - 0.0058
(3R)-3-hydroxydecanoyl-CoA
0.055
(3R)-hydroxybutyryl-CoA
-
A+/B+CtMFE-2(h2delta); A-/B+CtMFE-2(hdelta2deltaadelta)
0.024 - 0.025
(3R)-hydroxyhexadecanoyl-CoA
0.74
2-methylacetoacetyl-CoA
-
-
0.002 - 0.74
acetoacetyl-CoA
0.82
acetoacetyl-pantetheine
-
-
0.99
Acetoacetyl-S-(D-pantetheine)11-pivalate
-
-
0.006
beta-ketopalmitoyl-CoA
-
-
0.01
butyrylacetyl-CoA
-
-
0.026
D-3-hydroxybutyryl-CoA
-
-
0.03
D-beta-hydroxybutyryl-CoA
-
-
0.033
D-hydroxybutyryl-CoA
-
-
0.022
L-beta-hydroxybutyryl-CoA
-
-
0.25
NAD+
-
-
0.018 - 0.4
NADH
0.031 - 0.06
NADP+
0.018 - 0.041
NADPH
0.002
propionylacetyl-CoA
-
-
0.008 - 0.04
S-acetoacetyl-N-acetylcysteamine