1.1.1.36: acetoacetyl-CoA reductase

This is an abbreviated version, for detailed information about acetoacetyl-CoA reductase, go to the full flat file.

Reaction

(R)-3-hydroxyacyl-CoA
+
NADP+
=
3-oxoacyl-CoA
+
NADPH
+
H+

Synonyms

(3R)-hydroxyacyl-CoA dehydrogenase, (R)-3-hydroxyacyl-CoA dehydrogenase, acetoacetyl CoA reductase, acetoacetyl coenzyme A reductase, acetoacetyl-CoA reductase, beta-ketoacyl reductase, beta-ketoacyl-CoA reductase, beta-ketoacyl-coenzyme A reductase, D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase, D-3-hydroxyacyl-CoA dehydrogenase, D-3-hydroxyacyl-CoA reductase, D-specific 3-hydroxyacyl-CoA dehydrogenase, hydroxyacyl coenzyme-A dehydrogenase, KCR, MFE-2, More, NADP-linked acetoacetyl CoA reductase, NADPH-dependent acetoacetyl-CoA reductase, NADPH-linked acetoacetyl-CoA reductase, NADPH:acetoacetyl-CoA reductase, PHA-specific acetoacetyl-CoA reductase, PhaB, PhbB, polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase, polyhydroxybutyrate enzyme, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.36 acetoacetyl-CoA reductase

Engineering

Engineering on EC 1.1.1.36 - acetoacetyl-CoA reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A+/B+CtMFE-2(h2delta)
-
recombinant enzyme
A-/B+CtMFE-2(hdelta2deltaadelta)
-
domain A deleted
A-/B-CtMFE-2(hdelta2deltabdelta)
-
domain A and B deleted
D370A
-
site-directed mutagenesis
D490A
-
site-directed mutagenesis
D510A
-
site-directed mutagenesis, inactive
D517A
-
site-directed mutagenesis
E366A
-
site-directed mutagenesis, kcat/Km 100times lower than that of the wild type
E408A
-
site-directed mutagenesis
G16S
-
site-directed mutagenesis
H406A
-
site-directed mutagenesis
H515A
-
site-directed mutagenesis
H532A
-
site-directed mutagenesis
Y347A
-
site-directed mutagenesis
Y410A
-
site-directed mutagenesis
Y505A
-
site-directed mutagenesis
G16S
-
site-directed mutagenesis
G329S
-
site-directed mutagenesis
truncated version
additional information