1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxyacyl-CoA dehydrogenase, go to the full flat file.

Reaction

(S)-3-hydroxyacyl-CoA
+
NAD+
=
3-oxoacyl-CoA
+
NADH
+
H+

Synonyms

(S)-3-hydroxybutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase, 17beta-HSD10, 3-hydroxyacetyl-coenzyme A dehydrogenase, 3-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase II, 3-hydroxyacyl-coenzyme A dehydrogenase, 3-hydroxyadipyl-CoA dehydrogenase, 3-hydroxyadipyl-CoA dehydrogenase (NAD+) (probably (S)-3-specific), 3-hydroxyisobutyryl-CoA dehydrogenase, 3-keto reductase, 3-ketoacyl-CoA reductase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-L-hydroxybutyryl-CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, beta hydroxyacyl dehydrogenase, beta-hydroxy acid dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxybutyrylcoenzyme A dehydrogenase, beta-keto-reductase, beta-ketoacyl reductase, beta-ketoacyl-CoA reductase, beta-ketoacyl-coenzyme A reductase, betahydroxyacylcoenzyme A dehydrogenase, endoplasmic reticulum-associated amyloid beta-peptide binding protein, FadB, FadB2, Ferp_1035, Fum13p, HADH, HADH2, HADHSC, HCDH, KCR1, KCR2, L-3-hydroxyacyl CoA dehydrogenase, L-3-hydroxyacyl-CoA dehydrogenase, L-3-hydroxyacyl-CoA dehydrogenase, short chain, L-3-hydroxyacylcoenzyme A dehydrogenase, L-3-hydroxybutyryl CoA dehydrogenase, L-specific 3-hydroxyacyl-CoA dehydrogenase, medium- and short-chain-3-hydroxyacyl-CoA dehydrogenase, medium- and short-chain-3-hydroxyacyl-coenzyme A dehydrogenase, More, Msed_0399, multifunctional beta-oxidation enzyme, PaaH, SCHAD, SCHAD I, SCHAD II, SCHSD, Scully protein, short chain L-3-hydroxyacyl-CoA dehydrogenase, short-chain 3-hydroxyacyl-CoA dehydrogenase, short-chain 3-hydroxyacyl-coenzyme A dehydrogenase, short-chain hydroxyacyl CoA dehydrogenase, short-chain L-3-hydroxyacyl-CoA dehydrogenase, TFP, type 10 17beta-hydroxysteroid dehydrogenase, type II HADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.35 3-hydroxyacyl-CoA dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.35 - 3-hydroxyacyl-CoA dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.002
-
enzyme from brain, substrate 1-propanol
0.0121
-
enzyme from brain, substrate androsterone
0.0156
-
enzyme from brain, substrate 17beta-estradiol
0.033
-
enzyme activity in brain mitochondria, substrate acetoacetyl-CoA
0.087
-
enzyme from brain, substrate 5alpha-dihydrotestosterone
0.13
-
enzyme from brain, substrate dihydroandrosterone
0.41
-
enzyme activity in solubilized sediments of homogenized cells
0.48
-
enzyme activity in inner membrane of liver mitochondria, substrate acetoacetyl-CoA
0.5
85°C, pH 7.0, highly enriched enzyme
0.75
-
72% activivty is bound to the matrix surface of the inner mitochondria membrane, binding is inhibited by increasing ionic strength and pH
0.78
-
enzyme activity in kidney mitochondria, substrate acetoacetyl-CoA
1.5
-
enzyme activity in heart mitochondria, substrate acetoacetyl-CoA
1.67
-
enzyme activity in liver mitochondria, substrate acetoacetyl-CoA
2.3
-
enzyme activity in liver mitoplasts, substrate acetoacetyl-CoA
2.77
-
trans-3-decenoyl-CoA as a substrate
3 - 8
-
pH 8.0, 65°C, native enzyme, autotrophically- or heterotrophically-grown cell
3.4
-
enzyme activity in matrix of liver mitochondria, substrate acetoacetyl-CoA
4.17
-
(S)-3-hydroxydecanoyl-CoA as substrate, activity of L-specific 3-hydroxyacyl-CoA dehydrogenase in perMFE-I
4.22
-
(S)-3-hydroxybutyryl-CoA as substrate, activity of L-specific 3-hydroxyacyl-CoA dehydrogenase in perMFE-I
12.6
-
peroxisomal enzyme
17.35
enzyme from brain
23.4
-
L-3-hydroxyacyl-CoA dehydrogenase activity of the trifunctional beta-oxidation protein
40
-
purified enzyme
176
-
-
220
-
-
452
-
purified recombinant His-tagged wild-type enzyme
511
-
recombinant enzyme
565
-
mitochondrial enzyme
1200
-
His-tagged recombinant enzyme
additional information
-
the N-terminal His-tag does notinfluence enzyme activity