1.1.1.35: 3-hydroxyacyl-CoA dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxyacyl-CoA dehydrogenase, go to the full flat file.

Reaction

(S)-3-hydroxyacyl-CoA
+
NAD+
=
3-oxoacyl-CoA
+
NADH
+
H+

Synonyms

(S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase, (S)-3-hydroxybutyryl-CoA dehydrogenase, (S)-stereospecific 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase, 17beta-HSD10, 3-hydroxyacetyl-coenzyme A dehydrogenase, 3-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase II, 3-hydroxyacyl-coenzyme A dehydrogenase, 3-hydroxyadipyl-CoA dehydrogenase, 3-hydroxyadipyl-CoA dehydrogenase (NAD+) (probably (S)-3-specific), 3-hydroxybutyryl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 3-keto reductase, 3-ketoacyl-CoA reductase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-L-hydroxybutyryl-CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, beta hydroxyacyl dehydrogenase, beta-hydroxy acid dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxybutyrylcoenzyme A dehydrogenase, beta-keto-reductase, beta-ketoacyl reductase, beta-ketoacyl-CoA reductase, beta-ketoacyl-coenzyme A reductase, betahydroxyacylcoenzyme A dehydrogenase, CbHBD, endoplasmic reticulum-associated amyloid beta-peptide binding protein, F54C8.1, FadB, FadB', FadB2, Ferp_1035, Fum13p, H16_A0461, HAD, HADH, HADH2, HADHSC, HCDH, KCR1, KCR2, L-3-hydroxyacyl CoA dehydrogenase, L-3-hydroxyacyl-CoA dehydrogenase, L-3-hydroxyacyl-CoA dehydrogenase, short chain, L-3-hydroxyacylcoenzyme A dehydrogenase, L-3-hydroxybutyryl CoA dehydrogenase, L-specific 3-hydroxyacyl-CoA dehydrogenase, LIC13300, medium- and short-chain-3-hydroxyacyl-CoA dehydrogenase, medium- and short-chain-3-hydroxyacyl-coenzyme A dehydrogenase, More, Msed_0399, multifunctional beta-oxidation enzyme, PaaH, PaaH1, RePaaH1, SCHAD, SCHAD I, SCHAD II, SCHSD, Scully protein, short chain L-3-hydroxyacyl-CoA dehydrogenase, short-chain 3-hydroxyacyl-CoA dehydrogenase, short-chain 3-hydroxyacyl-coenzyme A dehydrogenase, short-chain hydroxyacyl CoA dehydrogenase, short-chain L-3-hydroxyacyl-CoA dehydrogenase, TFP, type 10 17beta-hydroxysteroid dehydrogenase, type II HADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.35 3-hydroxyacyl-CoA dehydrogenase

Reference

Reference on EC 1.1.1.35 - 3-hydroxyacyl-CoA dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pawar, S.; Schulz, H.
The structure of the multienzyme complex of fatty acid oxidation from Escherichia coli
J. Biol. Chem.
256
3894-3899
1981
Escherichia coli
Manually annotated by BRENDA team
Thieringer, R.; Kunau, W.H.
The beta-oxidation system in catalase-free microbodies of the filamentous fungus Neurospora crassa. Purification of a multifunctional protein possessing 2-enoyl-CoA hydratase, L-3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxyacyl-CoA epimerase activities
J. Biol. Chem.
266
13110-13117
1991
Neurospora crassa
Manually annotated by BRENDA team
Binstock, J.F.; Schulz, H.
Fatty acid oxidation complex from Escherichia coli
Methods Enzymol.
71
403-411
1981
Escherichia coli
Manually annotated by BRENDA team
Sumegi, B.; Srere, P.A.
Binding of the enzymes of fatty acid beta-oxidation and some related enzymes to pig heart inner mitochondrial membrane
J. Biol. Chem.
259
8748-8752
1984
Sus scrofa
Manually annotated by BRENDA team
Qin, Y.M.; Poutanen, M.H.; Helander, H.M.; Kvist, A.P.; Siivari, K.M.; Schmitz, W.; Conzelmann, E.; Hellman, U.; Hiltunen, J.K.
Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization
Biochem. J.
321
21-28
1997
Rattus norvegicus
Manually annotated by BRENDA team
Hillmer, P.; Gottschalk, G.
Solubilization and partial characterization of particulate dehydrogenases from Clostridium kluyveri
Biochim. Biophys. Acta
334
12-23
1974
Clostridium kluyveri
-
Manually annotated by BRENDA team
El-Fakhri, M.; Middleton, B.
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria
Biochim. Biophys. Acta
713
270-279
1982
Rattus norvegicus
Manually annotated by BRENDA team
Barycki, J.J.; O'Brian, L.K.; Bratt, J.M.; Zhang, R.; Sanishvili, R.; Strauss, A.W.; Banaszak, L.J.
Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism
Biochemistry
38
5786-5789
1999
Homo sapiens
Manually annotated by BRENDA team
He, X.Y.; Merz, G.; Mehta, P.; Schulz, H.; Yang, S.Y.
Human brain short chain L-3-hydroxyacyl Coenzyme A dehydrogenase is a singl-domain multifunctional enzyme
J. Biol. Chem.
274
15014-15019
1999
Homo sapiens
Manually annotated by BRENDA team
He, X.Y.; Yang, S.Y.
Molecular cloning, expression in Escherichia coli, and characterization of a novel L-3-hydroxyacyl coenzyme A dehydrogenase from pig liver
Biochim. Biophys. Acta
1392
119-126
1998
Sus scrofa
Manually annotated by BRENDA team
He, X.Y.; Schulz, H.; Yang, S.Y.
a human brain L-3-hydroxyacyl-coenzyme a dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease
J. Biol. Chem.
273
10741-10746
1998
Homo sapiens, Homo sapiens (Q99714)
Manually annotated by BRENDA team
Vredendaal, P.J.C.M.; van den Berg, I.E.T.; Malingre, H.E.M.; Stroobants, A.K.; Olde Weghuis, D.E.M.; Berger, R.
Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence
Biochem. Biophys. Res. Commun.
223
718-723
1996
Homo sapiens, Homo sapiens (Q16836)
Manually annotated by BRENDA team
Hartmann, D.; Philipp, R.; Schmadel, K.; Birktoft, J.J.; Banaszak, L.J.; Trommer, W.E.
Spatial arrangement of coenzyme and substrates bound to L-3-hydroxyacyl-CoA dehydrogenase as studied by spin-labeled analogues of NAD+ and CoA
Biochemistry
30
2782-2790
1991
Sus scrofa
Manually annotated by BRENDA team
Birktoft, J.J.; Holden, H.M.; Hamlin, R.; Xuong, N.H.; Banaszak, L.J.
Structure of L-3-hydroxyacyl-coenzyme A dehydrogenase: preliminary chain tracing at 2.8 A resolution
Proc. Natl. Acad. Sci. USA
84
8262-8266
1987
Sus scrofa
Manually annotated by BRENDA team
Holden, H.M.; Banaszak, L.J.
L-3-hydroxyacyl coenzyme a dehydrogenase
J. Biol. Chem.
258
2383-2389
1983
Sus scrofa
Manually annotated by BRENDA team
Holden, H.M.; Banaszak, L.J.; Frieden, C.; McLoughlin, D.J.
Differences in the binding of coenzyme to L-3-hydroxyacyl-Coenzyme A dehydrogenase in the crystalline state and in solution
FEBS Lett.
132
15-18
1981
Sus scrofa
Manually annotated by BRENDA team
Osumi, T.; Hashimoto, T.
Purification and properties of mitochondrial and peroxisomal 3-hydroxyacyl-CoA dehydrogenase from rat liver
Arch. Biochem. Biophys.
203
372-383
1980
Rattus norvegicus
Manually annotated by BRENDA team
Shimakata, T.; Fujita, Y.; Kusaka, T.
Purification and characterization of 3-hydroxyacyl-CoA dehydrogenase of Mycobacterium smegmatis
J. Biochem.
86
1191-1198
1979
Mycobacterium smegmatis
Manually annotated by BRENDA team
El-Fakhri, M.; Middleton, B.
The existence of two different L-3-hydroxyacyl-coenzymeA dehydrogenases in rat tissues
Biochem. Soc. Trans.
7
392-393
1979
Rattus norvegicus
Manually annotated by BRENDA team
Middleton, B.
3-Oxoacyl-coenzyme A thiolases and L-3-hydroxyacyl-coenzyme A dehydrogenases
Biochem. Soc. Trans.
6
80-83
1978
Rattus norvegicus
Manually annotated by BRENDA team
Bradshaw, R.A.; Noyes, B.E.
L-3-hydroxylacyl coenzyme A dehydrogenase from pig heart muscle
Methods Enzymol.
35
122-128
1975
Sus scrofa
Manually annotated by BRENDA team
Noyes, B.E.; Glatthaar, B.E.; Garavelli, J.S.; Bradshaw, R.A.
Structural and functional similarities between mitochondrial malate dehydrogenase and L-3-hydroxyacyl CoA dehydrogenase
Proc. Natl. Acad. Sci. USA
71
1334-1338
1974
Sus scrofa
Manually annotated by BRENDA team
Wininger, M.; Noyes, B.E.; Bradshaw, R.A.; Banaszak, L.J.
L-3-Hydroxacyl coenzyme A dehydrogenase: crystallographic properties of the pig heart enzyme
J. Mol. Biol.
90
409-413
1974
Sus scrofa
Manually annotated by BRENDA team
Noyes, B.E.; Bradshaw, R.A.
L-3-Hydroxyacyl coenzyme A dehydrogenase from pig heart muscle
J. Biol. Chem.
248
3052-3059
1973
Sus scrofa
Manually annotated by BRENDA team
Noyes, B.E.; Bradshaw, R.A.
L-3-Hydroxyacyl coenzyme A dehydrogenase from pig heart muscle. II. Subunit structure
J. Biol. Chem.
248
3060-3066
1973
Sus scrofa
-
Manually annotated by BRENDA team
Stern, J.R.
Crystalline beta-hydroxybutyryl dehydrogenase from pig heart
Biochim. Biophys. Acta
26
448-449
1957
Sus scrofa
Manually annotated by BRENDA team
Wakil, S.J.; Green, D.E.; Mil, S.; Mahler, H.R.
Studies on the fatty acid oxidizing system of animal tissues. IV. beta-hydroxyacyl coenzyme A dehydrogenase
J. Biol. Chem.
207
631-638
1954
Bos taurus
Manually annotated by BRENDA team
Winkler, U.; Saftel, W.; Stabenau, H.
A new type of a multifunctional beta-oxidation enzyme in Euglena
Plant Physiol.
131
753-762
2003
Euglena gracilis 1224-5/25, Euglena gracilis
Manually annotated by BRENDA team
Liu, X.; Chu, X.; Yu, W.; Li, P.; Li, D.
Expression and purification of His-tagged rat mitochondrial short-chain 3-hydroxyacyl-CoA dehydrogenase wild-type and Ser137 mutant proteins
Protein Expr. Purif.
37
344-351
2004
Rattus norvegicus
Manually annotated by BRENDA team
Puyaubert, J.; Dieryck, W.; Costaglioli, P.; Chevalier, S.; Breton, A.; Lessire, R.
Temporal gene expression of 3-ketoacyl-CoA reductase is different in high and in low erucic acid Brassica napus cultivars during seed development
Biochim. Biophys. Acta
1687
152-163
2005
Brassica napus, Brassica napus (Q84X95), Brassica napus (Q84X96)
Manually annotated by BRENDA team
van Hove, E.C.; Hansen, T.; Dekker, J.M.; Reiling, E.; Nijpels, G.; Jorgensen, T.; Borch-Johnsen, K.; Hamid, Y.H.; Heine, R.J.; Pedersen, O.; Maassen, J.A.; t Hart, L.M.
The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study
Diabetes
55
3193-3196
2006
Homo sapiens
Manually annotated by BRENDA team
He, X.; Yang, S.
Roles of type 10 17beta-hydroxysteroid dehydrogenase in intracrinology and metabolism of isoleucine and fatty acids
Endocr. Metab. Immune Disord. Drug Targets
6
95-102
2006
Homo sapiens
Manually annotated by BRENDA team
Yang, S.Y.; He, X.Y.; Schulz, H.
3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease
FEBS J.
272
4874-4883
2005
Homo sapiens, Homo sapiens (Q16836), Sus scrofa
Manually annotated by BRENDA team
Yi, H.; Bojja, R.S.; Fu, J.; Du, L.
Direct evidence for the function of FUM13 in 3-ketoreduction of mycotoxin fumonisins in Fusarium verticillioides
J. Agric. Food Chem.
53
5456-5460
2005
Fusarium verticillioides, Fusarium verticillioides A0149
Manually annotated by BRENDA team
Liu, W.; Chen, G.Q.
Production and characterization of medium-chain-length polyhydroxyalkanoate with high 3-hydroxytetradecanoate monomer content by fadB and fadA knockout mutant of Pseudomonas putida KT2442
Appl. Microbiol. Biotechnol.
76
1153-1159
2007
Pseudomonas putida, Pseudomonas putida KT 2442
Manually annotated by BRENDA team
Filling, C.; Keller, B.; Hirschberg, D.; Marschall, H.U.; Joernvall, H.; Bennett, M.J.; Oppermann, U.
Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency
Biochem. Biophys. Res. Commun.
368
6-11
2008
Homo sapiens
Manually annotated by BRENDA team
Liu, X.; Deng, G.; Chu, X.; Li, N.; Wu, L.; Li, D.
Formation of an enolate intermediate is required for the reaction catalyzed by 3-hydroxyacyl-CoA dehydrogenase
Bioorg. Med. Chem. Lett.
17
3187-3190
2007
Rattus norvegicus
Manually annotated by BRENDA team
Martens, G.A.; Vervoort, A.; Van de Casteele, M.; Stange, G.; Hellemans, K.; Van Thi, H.V.; Schuit, F.; Pipeleers, D.
Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release
J. Biol. Chem.
282
21134-21144
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Hiltunen, J.K.
Peroxisomes and beta-oxidation of long-chain unsaturated carboxylic acids
Scand. J. Clin. Lab. Invest. Suppl.
204
33-46
1991
Rattus norvegicus
Manually annotated by BRENDA team
Yang, S.; He, X.
Re: Hadh2 and 3-hydroxyacyl-CoA dehydrogenase
Am. J. Physiol. Endocrinol. Metab.
295
E987-E987
2008
Mus musculus
Manually annotated by BRENDA team
Chung, A.; Liu, Q.; Ouyang, S.P.; Wu, Q.; Chen, G.Q.
Microbial production of 3-hydroxydodecanoic acid by pha operon and fadBA knockout mutant of Pseudomonas putida KT2442 harboring tesB gene
Appl. Microbiol. Biotechnol.
83
513-519
2009
Pseudomonas putida
Manually annotated by BRENDA team
Kapoor, R.R.; James, C.; Flanagan, S.E.; Ellard, S.; Eaton, S.; Hussain, K.
3-Hydroxyacyl-coenzyme A dehydrogenase deficiency and hyperinsulinemic hypoglycemia: characterization of a novel mutation and severe dietary protein sensitivity
J. Clin. Endocrinol. Metab.
94
2221-2225
2009
Homo sapiens
Manually annotated by BRENDA team
Beaudoin, F.; Wu, X.; Li, F.; Haslam, R.P.; Markham, J.E.; Zheng, H.; Napier, J.A.; Kunst, L.
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase
Plant Physiol.
150
1174-1191
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Taylor, R.C.; Brown, A.K.; Singh, A.; Bhatt, A.; Besra, G.S.
Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis
Microbiology
156
1975-1982
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WNP7), Mycobacterium tuberculosis ATCC 25618 (P9WNP7)
Manually annotated by BRENDA team
Teufel, R.; Mascaraque, V.; Ismail, W.; Voss, M.; Perera, J.; Eisenreich, W.; Haehnel, W.; Fuchs, G.
Bacterial phenylalanine and phenylacetate catabolic pathway revealed
Proc. Natl. Acad. Sci. USA
107
14390-14395
2010
Escherichia coli, Pseudomonas sp., Pseudomonas sp. Y2
Manually annotated by BRENDA team
Schulz, N.; Himmelbauer, H.; Rath, M.; van Weeghel, M.; Houten, S.; Kulik, W.; Suhre, K.; Scherneck, S.; Vogel, H.; Kluge, R.; Wiedmer, P.; Joost, H.G.; Schuermann, A.
Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis
Endocrinology
152
4641-4651
2011
Mus musculus
Manually annotated by BRENDA team
Narayan, S.B.; Master, S.R.; Sireci, A.N.; Bierl, C.; Stanley, P.E.; Li, C.; Stanley, C.A.; Bennett, M.J.
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways
PLoS ONE
7
e35048
2012
Mus musculus
Manually annotated by BRENDA team
Hawkins, A.B.; Adams, M.W.; Kelly, R.M.
Conversion of 4-hydroxybutyrate to acetyl coenzyme A and its anapleurosis in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
Appl. Environ. Microbiol.
80
2536-2545
2014
Metallosphaera sedula (A4YDS4), Metallosphaera sedula DSM 5348 (A4YDS4)
Manually annotated by BRENDA team
Ramos-Vera, W.H.; Weiss, M.; Strittmatter, E.; Kockelkorn, D.; Fuchs, G.
Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota
J. Bacteriol.
193
1201-1211
2011
Metallosphaera sedula (A4YDS4), Metallosphaera sedula DSM 5348 (A4YDS4)
Manually annotated by BRENDA team
Schmid, G.; René, S.B.; Boll, M.
Enzymes of the benzoyl-coenzyme A degradation pathway in the hyperthermophilic archaeon Ferroglobus placidus
Environ. Microbiol.
17
3289-3300
2015
Ferroglobus placidus (D3RXI4), Ferroglobus placidus DSM 10642 (D3RXI4)
Manually annotated by BRENDA team
Xu, Y.; Sun, F.
Purification, crystallization and preliminary crystallographic analysis of 3-hydroxyacyl-CoA dehydrogenase from Caenorhabditis elegans
Acta Crystallogr. Sect. F
69
515-519
2013
Caenorhabditis elegans, Caenorhabditis elegans (P34439)
Manually annotated by BRENDA team
Kim, E.; Kim, K.
Cloning, expression, purification, crystallization and X-ray crystallographic analysis of (S)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium butyricum
Acta Crystallogr. Sect. F
70
485-488
2014
Clostridium butyricum (C4IEM5), Clostridium butyricum
Manually annotated by BRENDA team
Kim, J.; Kim, K.
Cloning, expression, purification, crystallization and X-ray crystallographic analysis of the (S)-3-hydroxybutyryl-CoA dehydrogenase PaaH1 from Ralstonia eutropha H16
Acta Crystallogr. Sect. F
70
955-958
2014
Cupriavidus necator, Cupriavidus necator (Q0KEY8), Cupriavidus necator ATCC 17699 (Q0KEY8)
Manually annotated by BRENDA team
Volodina, E.; Steinbuechel, A.
(S)-3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase (FadB) from fatty acid degradation operon of Ralstonia eutropha H16
AMB Express
4
69
2014
Cupriavidus necator (Q0KEG0), Cupriavidus necator DSM 428 (Q0KEG0)
Manually annotated by BRENDA team
Kim, J.; Chang, J.H.; Kim, K.J.
Crystal structure and biochemical properties of the (S)-3-hydroxybutyryl-CoA dehydrogenase PaaH1 from Ralstonia eutropha
Biochem. Biophys. Res. Commun.
448
163-168
2014
Cupriavidus necator, Cupriavidus necator (Q0KEY8), Cupriavidus necator ATCC 17699 (Q0KEY8)
Manually annotated by BRENDA team
Segawa, T.; Nomura, K.H.; Villanueva, S.Y.; Saito, M.; Nomura, K.; Gloriani, N.G.; Yoshida, S.
Identification of leptospiral 3-hydroxyacyl-CoA dehydrogenase released in the urine of infected hamsters
BMC Microbiol.
14
132
2014
Leptospira interrogans serovar Copenhageni (Q72M90), Leptospira interrogans serovar Copenhageni Fiocruz LV4231 (Q72M90)
Manually annotated by BRENDA team
Heslegrave, A.; Hussain, K.
Novel insights into fatty acid oxidation, amino acid metabolism, and insulin secretion from studying patients with loss of function mutations in 3-hydroxyacyl-CoA dehydrogenase
J. Clin. Endocrinol. Metab.
98
496-501
2013
Homo sapiens, Homo sapiens (Q16836)
Manually annotated by BRENDA team
Kim, E.J.; Kim, J.; Ahn, J.W.; Kim, Y.J.; Chang, J.H.; Kim, K.J.
Crystal structure of (S)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium butyricum and its mutations that enhance reaction kinetics
J. Microbiol. Biotechnol.
24
1636-1643
2014
Clostridium butyricum (C4IEM5), Clostridium butyricum
Manually annotated by BRENDA team
Xu, Y.; Li, H.; Jin, Y.H.; Fan, J.; Sun, F.
Dimerization interface of 3-hydroxyacyl-CoA dehydrogenase tunes the formation of its catalytic intermediate
PLoS ONE
9
e95965
2014
Caenorhabditis elegans, Caenorhabditis elegans (P34439), Homo sapiens, Homo sapiens (Q16836)
Manually annotated by BRENDA team