1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+)

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For detailed information about D-2-hydroxyacid dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

D-2-HADH, D-2-hydroxyacid dehydrogenase, D-2-hydroxyisocaproate dehydrogenase, D-HicDH, D-isomer specific 2-hydroxyacid dehydrogenase, D-isomer specific NAD+-dependent 2-hydroxyacid dehydrogenase, D-isomer-specific 2-hydroxyacid dehydrogenase, D-lactate dehydrogenase, D-lactate:NAD+ oxidoreductase, D-malate dehydrogenases, D-mandelate dehydrogenase, D-ManDH1, D-ManDH2, D-MDH, D2-HDH, HdhD, Ldb1010, ldh1837, LEUM_1837, ManDH2, NAD-dependent D-2-hydroxyacid dehydrogenase, PanE, R-HicDH

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)

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Results	in table
4	Activating Compound
5	AA Sequence
1	Application
12	Cloned(Commentary)
14	Cofactor
5	Crystallization (Commentary)
24	General Information
19	Inhibitors
10	kcat/KM [mM/s]
70	KM Value [mM]
2	Metals/Ions
21	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
42	Organism
3	Pathway
14	pH Optimum
4	pH Range
2	pH Stability
1	Protein Variants
10	Purification (Commentary)
1	Reaction
33	Reference
8	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
152	Substrates and Products (Substrate)
25	Subunits
96	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
11	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 1.1.1.345 - D-2-hydroxyacid dehydrogenase (NAD+)

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

37 - 55

Lactococcus lactis

-

at 37°C, the activity reaches about 65% of peak activity at 55°C

712292

65 - 75

Haloferax mediterranei

-

above 60°C there is a pronounced activity decrease, while there is nearly no activity at 75°C

672434