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1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about D-2-hydroxyacid dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.345

Reaction

an (R)-2-hydroxycarboxylate
+
NAD+
=
a 2-oxocarboxylate
+
NADH
+
H+

Synonyms

D-2-HADH, D-2-hydroxyacid dehydrogenase, D-2-hydroxyisocaproate dehydrogenase, D-HicDH, D-isomer specific 2-hydroxyacid dehydrogenase, D-isomer specific NAD+-dependent 2-hydroxyacid dehydrogenase, D-isomer-specific 2-hydroxyacid dehydrogenase, D-lactate dehydrogenase, D-lactate:NAD+ oxidoreductase, D-malate dehydrogenases, D-mandelate dehydrogenase, D-ManDH1, D-ManDH2, D-MDH, D2-HDH, HdhD, Ldb1010, ldh1837, LEUM_1837, ManDH2, NAD-dependent D-2-hydroxyacid dehydrogenase, PanE, R-HicDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)

KCat KM Value

KCat KM Value on EC 1.1.1.345 - D-2-hydroxyacid dehydrogenase (NAD+)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
18
(R)-2-hydroxy-4-methylpentanoate
-
pH 7.0, temperature not specified in the publication
9.7
2-hydroxyhexanoate
-
pH 7.0, temperature not specified in the publication
25
2-Hydroxyoctanoate
-
pH 7.0, temperature not specified in the publication
7.2
2-hydroxypentanoate
-
pH 7.0, temperature not specified in the publication
1100
2-Oxohexanoate
-
pH 7.0, temperature not specified in the publication
139
2-oxooctanoate
-
pH 7.0, temperature not specified in the publication
1600
2-oxopentanoate
-
pH 7.0, temperature not specified in the publication
1300
3-(4-hydroxyphenyl)-2-oxopropanoate
-
pH 7.0, temperature not specified in the publication
210
4-methyl-2-oxopentanoate
-
pH 7.0, temperature not specified in the publication
4800
phenylpyruvate
-
pH 7.0, temperature not specified in the publication