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1.1.1.345: D-2-hydroxyacid dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about D-2-hydroxyacid dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.345

Reaction

an (R)-2-hydroxycarboxylate
+
NAD+
=
a 2-oxocarboxylate
 +
NADH
 +
H+

Synonyms

D-2-HADH, D-2-hydroxyacid dehydrogenase, D-2-hydroxyisocaproate dehydrogenase, D-HicDH, D-isomer specific 2-hydroxyacid dehydrogenase, D-isomer specific NAD+-dependent 2-hydroxyacid dehydrogenase, D-isomer-specific 2-hydroxyacid dehydrogenase, D-lactate dehydrogenase, D-lactate:NAD+ oxidoreductase, D-malate dehydrogenases, D-mandelate dehydrogenase, D-ManDH1, D-ManDH2, D-MDH, D2-HDH, HdhD, Ldb1010, ldh1837, LEUM_1837, ManDH2, NAD-dependent D-2-hydroxyacid dehydrogenase, PanE, R-HicDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)

Inhibitors

Inhibitors on EC 1.1.1.345 - D-2-hydroxyacid dehydrogenase (NAD+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
10 mM, decrease of 13% in the enzymatic activity
2-Oxohexanoate
substrate inhibition
2-oxopentanoate
substrate inhibition
4-methyl-2-oxopentanoate
substrate inhibition
Ca2+
-
72% residual activity at 1 mM
CaCl2
-
1 mM, 28% inhibition
Cu2+
-
complete inhibition at 0.1 mM
CuSO4
-
0.1 mM, complete inhibition
DEPC
-
65% residual activity at 1 mM, 12% residual activity at 2 mM
diethyl dicarbonate
-
2 mM, 88% inhibition
HgCl2
-
0.1 mM, complete inhibition
iodoacetamide
Mg2+
-
83% residual activity at 1 mM
MgCl2
-
1 mM, 17% inhibition
phenylpyruvate
substrate inhibition
additional information
the addition of citrate and EDTA (up to 10 mM) has no effect on the enzymatic activity. The addition of of iodoacetamide, KCN, 2-mercaptoethanol, dithiothreitol, and reduced glutathione in concentrations up to 20 mM has no effect
-