1.1.1.312: 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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For detailed information about 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 2-hydroxy-4-carboxymuconate-6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, CHMS dehydrogenase, CHMS hydrolase, dehydrogenase, 2-hydroxy-4-carboxymuconate 6-semialdehyde, EC 1.2.1.45, PmdC

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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1	Activating Compound
508	AA Sequence
5	Application
1	CAS Registry Number
5	Cloned(Commentary)
9	Cofactor
15	Inhibitors
5	Ki Value [mM]
11	KM Value [mM]
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
18	Organism
6	Pathway
3	pH Optimum
1	pH Range
1	pH Stability
1	Protein Variants
3	Purification (Commentary)
2	Reaction
5	Reaction Type
10	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
23	Substrates and Products (Substrate)
6	Subunits
17	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 1.1.1.312 - 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase

The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].