1.1.1.30: 3-hydroxybutyrate dehydrogenase
This is an abbreviated version!
For detailed information about 3-hydroxybutyrate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.30
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1.1.1.30
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ketone
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succinate
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acetoacetate
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lipid-requiring
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lecithin
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coa-transferase
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acetoacetyl-coa
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alpha-glycerophosphate
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thiolase
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3-oxoacid
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submitochondrial
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ketogenesis
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enzyme-phospholipid
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analysis
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diagnostics
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synthesis
- 1.1.1.30
- ketone
- succinate
- acetoacetate
-
lipid-requiring
- lecithin
-
coa-transferase
- acetoacetyl-coa
- alpha-glycerophosphate
-
thiolase
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3-oxoacid
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submitochondrial
-
ketogenesis
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enzyme-phospholipid
- analysis
- diagnostics
- synthesis
Reaction
Synonyms
3-D-hydroxybutyrate dehydrogenase, 3-HBDH, 3-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase 2, 3-hydroxybutyrate dehydrogenase-2, 3HBDH, acetoacetyl-CoA reductase, BDH, BDH1, BDH2, BDH3, BdhA, beta-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, beta-hydroxybutyric dehydrogenase, D(-)-3-hydroxybutyrate dehydrogenase, D-(-)-3-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, DHRS6, HBD, HBDH, hydroxybutyrate oxidoreductase, More, NAD-beta-hydroxybutyrate dehydrogenase, Psyc_1428
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.30 - 3-hydroxybutyrate dehydrogenase
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REACTION DIAGRAM
(R)-2-hydroxybutanoate + NAD+
acetoacetate + NADH
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isoenzyme from heavy mitochondria and isoenzyme from light mitochondria show no significant difference in activity
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?
(R)-3-hydroxybutanoate + 3-acetylpyridine adenine dinucleotide
acetoacetate + 3-acetylpyridine adenine dinucleotideH2
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-
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r
(R)-3-hydroxybutanoate + NADP+
acetoacetate + NADPH
activity with NADP+ is 2% of the activity with NAD+
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?
2-methyl-3-hydroxybutyrate + NAD+
2-methylacetoacetate + NADH
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-
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r
4-hydroxybutanoate + NAD+
acetoacetate + NADH
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isoenzyme from heavy mitochondria shows 40% lower activity than enzyme fromlight mitochondria
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?
acetoacetate + NADH + H+
(R)-3-hydroxybutanoate + NAD+
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-
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?
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
model of the binding mode of the substrate D-3-hydroxybutyrate, Gln193 is the only residue of the substrate-binding loop that interacts directly with the substrate, NAD+ binding increases the flexibility of the substrate-binding loop and shifts the equilibrium between the open and closed forms towards the closed form, overview
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r
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
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?
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
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-
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?
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
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-
-
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?
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
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r
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
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-
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r
(R)-3-hydroxybutanoate + NADH + H+
acetoacetate + NAD+
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the enzyme is involved in poly(3-hydroxybutyrate) biosynthesis together with acetoacetyl-CoA thiolase and PHB synthase, pathway overview, intracellular concentrations of key metabolites, i.e. CoA, acetyl-CoA, 3HB-CoA, NAD+/NADH, determine whether a cell accumulates or degrades PHB
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r
(R)-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
strain SA1 can degrade poly((R)-3-hydroxybutyrate), i.e. PHB
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r
(R)-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
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during hibernation, the enzyme is responsible for bioconvertion of high amounts of ketone bodies, i.e. acetoacetate and (R)-3-hydroxybutyrate, in the liver for usage as energetic fuel
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r
3-hydroxyvalerate + NAD+
3-oxovalerate + NADH + H+
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-
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?
acetoacetate + NADH + H+
the reversible reactions occur by shuttle movements of a hydrogen negative ion from the C3 atom of the substrate to the C4 atom of NAD+ and from the C4 atom of NADH to the C3 atom of the product. The reaction may be further coupled to the withdrawal of a proton from the hydroxyl group of the substrate by the ionized Tyr155 residue
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r
D-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
BDH1 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate
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r
D-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
BDH2 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate
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r
D-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
BDH3 is specialized to utilize 3-hydroxybutyrate
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r
D-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
BDH3 is specialized to utilize 3-hydroxybutyrate
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r
D-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
BDH2 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate
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r
D-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
BDH1 is needed to regulate the cytoplasmic redox state as well as to utilize 3-hydroxybutyrate
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r
4-hydroxyvaleric acid + NAD+
only the recombinant wild type enzyme with N-terminal His-tag shows activity with levulinic acid
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?
levulinic acid + NADH + H+
4-hydroxyvaleric acid + NAD+
the wild type enzyme shows low activity with levulinic acid, while it's a good substrate for mutant enzyme H144L/W187F
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?
acetoacetate + NADH + H+
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r
poly-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
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r
?
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no activity of the wild-type enzyme with levulinic acid, enzyme mutant H144L/W187F is active with levulinic acid producing 4-hydroxyvaleric acid
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?
additional information
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enzyme activity is differently regulated in liver and brain at euthermic, prehibernating,and hibernating state
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?
additional information
?
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a ketone body converting enzyme in mitochondria in liver jerboa, enzyme expression, activity and metabolism at different physiological states, overview
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?