1.1.1.30: 3-hydroxybutyrate dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxybutyrate dehydrogenase, go to the full flat file.

Reaction

(R)-3-hydroxybutanoate
+
NAD+
=
acetoacetate
+
NADH
+
H+

Synonyms

3-D-hydroxybutyrate dehydrogenase, 3-HBDH, 3-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase 2, 3-hydroxybutyrate dehydrogenase-2, 3HBDH, acetoacetyl-CoA reductase, BDH, BDH1, BDH2, BDH3, BdhA, beta-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, beta-hydroxybutyric dehydrogenase, D(-)-3-hydroxybutyrate dehydrogenase, D-(-)-3-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, DHRS6, HBD, HBDH, hydroxybutyrate oxidoreductase, More, NAD-beta-hydroxybutyrate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.30 3-hydroxybutyrate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.30 - 3-hydroxybutyrate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-2-hydroxybutanoate + NAD+
acetoacetate + NADH
show the reaction diagram
-
isoenzyme from heavy mitochondria and isoenzyme from light mitochondria show no significant difference in activity
-
-
?
(R)-3-hydroxybutanoate + 3-acetylpyridine adenine dinucleotide
acetoacetate + 3-acetylpyridine adenine dinucleotideH2
show the reaction diagram
-
-
-
r
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH
show the reaction diagram
(R)-3-hydroxybutanoate + NAD+
acetoacetate + NADH + H+
show the reaction diagram
(R)-3-hydroxybutanoate + NADH + H+
acetoacetate + NAD+
show the reaction diagram
(R)-3-hydroxybutanoate + NADP+
acetoacetate + NADPH
show the reaction diagram
activity with NADP+ is 2% of the activity with NAD+
-
-
?
(R)-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
show the reaction diagram
2-hydroxypropansulfonate + NAD+
acetonylsulfonate + NADH
show the reaction diagram
-
-
-
r
2-methyl-3-hydroxybutyrate + NAD+
2-methylacetoacetate + NADH
show the reaction diagram
-
-
-
r
3-hydroxyvalerate NAD+
3-oxovalerate + NADH + H+
show the reaction diagram
4-hydroxybutanoate + NAD+
acetoacetate + NADH
show the reaction diagram
-
isoenzyme from heavy mitochondria shows 40% lower activity than enzyme fromlight mitochondria
-
-
?
acetoacetate + NADH + H+
(R)-3-hydroxybutanoate + NAD+
show the reaction diagram
-
-
-
-
?
D-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
show the reaction diagram
L-threonine + NAD+
?
show the reaction diagram
-
-
-
?
levulinic acid + NADH + H+
4-hydroxyvaleric acid + NAD+
show the reaction diagram
poly-3-hydroxybutyrate + NAD+
acetoacetate + NADH + H+
show the reaction diagram
additional information
?
-