1.1.1.30: 3-hydroxybutyrate dehydrogenase

This is an abbreviated version, for detailed information about 3-hydroxybutyrate dehydrogenase, go to the full flat file.

Reaction

(R)-3-hydroxybutanoate
+
NAD+
=
acetoacetate
+
NADH
+
H+

Synonyms

3-D-hydroxybutyrate dehydrogenase, 3-HBDH, 3-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase 2, 3-hydroxybutyrate dehydrogenase-2, 3HBDH, acetoacetyl-CoA reductase, BDH, BDH1, BDH2, BDH3, BdhA, beta-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, beta-hydroxybutyric dehydrogenase, D(-)-3-hydroxybutyrate dehydrogenase, D-(-)-3-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, DHRS6, HBD, HBDH, hydroxybutyrate oxidoreductase, More, NAD-beta-hydroxybutyrate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.30 3-hydroxybutyrate dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.30 - 3-hydroxybutyrate dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.02
-
cofactor 3-acetylpyridine adenine dinucleotide
0.038
-
brain 3-hydroxybutyrate dehydrogenase, mitochondrial extracts
0.07
-
heart 3-hydroxybutyrate dehydrogenase, mitochondrial extracts; kidney 3-hydroxybutyrate dehydrogenase, mitochondrial extracts
0.09
-
purified enzyme
0.17
-
solubilized apo-3-hydroxybutyrate dehydrogenase, reconstituted with phosphatidylcholine/phosphatidylethanolamine/diphosphatidylglycerol, 5/4/1
0.22
-
apo-3-hydroxybutyrate dehydrogenase, reconstituted with phosphatidylcholine/phosphatidylethanolamine/diphosphatidylglycerol, 5/4/1
0.5
-
enzyme expressed in SF9 cells, S24T mutatant
0.52
-
submitochondrial vesicles, membrane bound enzyme
0.54
-
submitochondrial vesicles
0.6
-
enzyme expressed in SF9 cells, M92V mutatant
0.63
-
enzyme expressed in SF9 cells, membrane bound
0.8
-
enzyme expressed in SF9 cells, C242S mutatant
1.15
-
liver 3-hydroxybutyrate dehydrogenase, reconstituted with microsomal membranes
1.26
-
brain 3-hydroxybutyrate dehydrogenase, mitochondrial extracts
1.275
-
liver 3-hydroxybutyrate dehydrogenase, reconstituted with mitochondrial inner membranes
2.7
-
submitochondrial vesicles
23.8
-
-
41
-
purified enzyme, reconstituted with mitochondrial phospholipids
72
purified native enzyme
86
-
purified enzyme, reconstituted with mitochondrial phospholipids
91
-
liver 3-hydroxybutyrate dehydrogenase, reconstituted with mitochondrial phospholipids
100
-
-
145
-
heart 3-hydroxybutyrate dehydrogenase, reconstituted with mitochondrial phospholipids
300
purified recombinant enzyme
360
recombinant enzyme
450
recombinant enzyme
additional information
-
0.0018 mM/min/g wet weight