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1.1.1.30: 3-hydroxybutyrate dehydrogenase

This is an abbreviated version!
For detailed information about 3-hydroxybutyrate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.30

Reaction

(R)-3-hydroxybutanoate
+
NAD+
=
acetoacetate
+
NADH
+
H+

Synonyms

3-D-hydroxybutyrate dehydrogenase, 3-HBDH, 3-hydroxybutyrate dehydrogenase, 3-hydroxybutyrate dehydrogenase 2, 3-hydroxybutyrate dehydrogenase-2, 3HBDH, acetoacetyl-CoA reductase, BDH, BDH1, BDH2, BDH3, BdhA, beta-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, beta-hydroxybutyric dehydrogenase, D(-)-3-hydroxybutyrate dehydrogenase, D-(-)-3-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, DHRS6, HBD, HBDH, hydroxybutyrate oxidoreductase, More, NAD-beta-hydroxybutyrate dehydrogenase, Psyc_1428

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.30 3-hydroxybutyrate dehydrogenase

Disease

Disease on EC 1.1.1.30 - 3-hydroxybutyrate dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Brain Neoplasms
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer.
Carcinoma
Monitoring by alpha-hydroxybutyrate dehydrogenase of human ovarian carcinoma grown in nude mice.
Carcinoma, Hepatocellular
Immunochemical analysis of the membrane proteins of rat liver and Zajdela hepatoma mitochondria.
Regulation of D-beta-hydroxybutyrate dehydrogenase in rat hepatoma cell lines.
[Activity of the beta-hydroxybutyric dehydrogenase of mitochondria of ascitic hepatoma and of the normal rat liver.]
Cardiomegaly
Cardiac hypertrophy in spontaneously hypertensive rats. Ultrastructural cytochemistry of beta-hydroxybutyrate dehydrogenase [proceedings]
Proceedings: Cardiac hypertrophy in spontaneously hypertensive rats. I. Chronological changes in the mitochondrial beta-hydroxybutyrate dehydrogenase activity in the myocardium.
Diabetes Mellitus
Metabolic control of the expression of mitochondrial D-beta-hydroxybutyrate dehydrogenase, a ketone body converting enzyme.
The effect of spontaneous diabetes mellitus on fatty acid oxidation, beta-hydroxybutyrate dehydrogenase activity and respiratory coupling of hepatic mitochondria in the guinea-pig (Cavia porcellus).
The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family.
Diabetes Mellitus, Experimental
Variations of specific mRNA and polypeptide contents of rat liver D-beta-hydroxybutyrate dehydrogenase during an experimental diabetes mellitus.
Fatty Liver
Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting.
Glioma
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
Heart Failure
[Histochemical study of the enzyme activity of the myocardium of sudden death victims with postinfarct cardiosclerosis]
Hutchinson's Melanotic Freckle
Histochemical findings in different types of malignant melanoma: biological and clinical significance.
Hyperthyroidism
Accelerated postnatal development of D(-)- -hydroxybutyrate dehydrogenase (EC 1.1.1.30) activity in the brain in hyperthyroidism.
Concerning the decreased D-3-hydroxybutyrate dehydrogenase activity in the liver and heart of hyperthyroid rats.
Differential action of thyroid hormones on the activity of certain enzymes in rat kidney and brain.
Ketone-body metabolism in hyperthyroid rats: reduced activity of D-3-hydroxybutyrate dehydrogenase in both liver and heart and of succinyl-coenzyme A: 3-oxoacid coenzyme A-transferase in heart.
Hypothyroidism
Mitochondrial oxidative enzyme activity in individual fibre types in hypo- and hyperthyroid rat skeletal muscles.
[Enzymatic and immunologic study of the role of the thyroid hormone in the formation of the internal mitochondrial membrane during postnatal development of the rat]
Infections
Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages.
Iron Deficiencies
3-Hydroxybutyrate dehydrogenase-2 and ferritin-H synergistically regulate intracellular iron.
Ketosis
Effect of prenatally-induced and postnatally-maintained ketosis on beta-hydroxybutyrate dehydrogenase and hexokinase levels in the developing rat brain.
The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family.
Melanoma
Histochemical findings in different types of malignant melanoma: biological and clinical significance.
Nasopharyngeal Carcinoma
Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention.
Neoplasm Metastasis
Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention.
Neoplasms
Beta-hydroxybutyrate dehydrogenase activity in liver and liver tumors.
Fatty acid oxidation, substrate shuttles, and activity of the citric acid cycle in hepatocellular carcinomas of varying differentiation.
Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues.
Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo.
Monitoring by alpha-hydroxybutyrate dehydrogenase of human ovarian carcinoma grown in nude mice.
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer.
Obesity
Treatment with the 5-HT3 antagonist tropisetron modulates glucose-induced obesity in mice.
Reperfusion Injury
[Transmural differences between damaged cardiomyocytes due to post-ischemic reperfusion and calcium paradox]
Starvation
Activities of some key enzymes of carbohydrate, ketone body, adenosine and glutamine metabolism in liver, and brown and white adipose tissues of the rat.
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.