1.1.1.3: homoserine dehydrogenase

This is an abbreviated version, for detailed information about homoserine dehydrogenase, go to the full flat file.

Reaction

L-homoserine
+
NAD(P)+
=
L-aspartate 4-semialdehyde
+
NAD(P)H
+
H+

Synonyms

AK-HDH, AK-HSD-1, AK-HSDH, aspartate kinase-homoserine dehydrogenase, aspartokinase-homoserine dehydrogenase I, HDH, hom, hom-1, Hom6, homoserine dehydrogenase 1, homoserine dehydrogenase 2, HSD, HSDH, HseDH, orf19.2951, SACOL1362

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.3 homoserine dehydrogenase

KI Value

KI Value on EC 1.1.1.3 - homoserine dehydrogenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0131
(2S)-2-[[4-(propan-2-yl)phenyl]sulfanyl]propanenitrile
pH and temperature not specified in the publication
0.01307
1-tert-butyl-4-[(difluoromethyl)sulfanyl]benzene
pH and temperature not specified in the publication
0.00963
1-[(1S,2S)-2-(bromomethyl)cyclopropyl]-4-[(trifluoromethyl)sulfanyl]benzene
pH and temperature not specified in the publication
0.01568
3-[(4-tert-butylphenyl)sulfanyl]propane-1-thiol
pH and temperature not specified in the publication
0.01
4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol
pH and temperature not specified in the publication
-
160 - 240
L-threonine
pH 8.0, 25C
0.0000052
NADP+
pH 9.0, 50C, recombinant wild-type enzyme