1.1.1.290: 4-phosphoerythronate dehydrogenase

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For detailed information about 4-phosphoerythronate dehydrogenase, go to the full flat file.

Reaction

Synonyms

4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.290 4-phosphoerythronate dehydrogenase

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Results	in table
7336	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
7	Cofactor
2	Crystallization (Commentary)
4	General Information
2	IC50 Value
3	Inhibitors
5	kcat/KM [mM/s]
2	Ki Value [mM]
5	KM Value [mM]
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
11	PDB ID
1	pH Optimum
3	Purification (Commentary)
2	Reaction
3	Reaction Type
10	Reference
21	Substrates and Products (Substrate)
2	Subunits
17	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
5	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.290 - 4-phosphoerythronate dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

4-phospho-D-erythronate:NAD+ 2-oxidoreductase

This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC 1.1.1.399, 2-oxoglutarate reductase.