1.1.1.286: isocitrate-homoisocitrate dehydrogenase

This is an abbreviated version!
For detailed information about isocitrate-homoisocitrate dehydrogenase, go to the full flat file.

Reaction

(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

Synonyms

3-carboxy-2-hydroxyadipate dehydrogenase, HICDH, homoisocitrate dehydrogenase, isocitrate-homoisocitrate dehydrogenase, More, Saci_2375, TK0280

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.286 isocitrate-homoisocitrate dehydrogenase

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Results	in table
13	AA Sequence
2	CAS Registry Number
5	Cloned(Commentary)
8	Cofactor
2	Crystallization (Commentary)
14	General Information
11	Inhibitors
36	kcat/KM [mM/s]
4	Ki Value [mM]
51	KM Value [mM]
9	Metals/Ions
3	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
12	Organism
15	Pathway
4	pH Optimum
1	pH Range
17	Protein Variants
4	Purification (Commentary)
4	Reaction
12	Reference
42	Substrates and Products (Substrate)
9	Subunits
20	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
33	Turnover Number [1/s]

Cofactor

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Cofactor on EC 1.1.1.286 - isocitrate-homoisocitrate dehydrogenase

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NAD+

5 entries

NADH

Thermus thermophilus

Q72IW9

NADH forms specific contacts with enzyme TtHICDH. The 2'- and 3-OHs of the adenine ribose of NADH form hydrogen bonds with Asp265 conserved among HICDHs, which may serve as a determinant for the preference of HICDH family members for NAD+ to NADP+

740000

NADP+

Sulfolobus acidocaldarius

Q4J6C9

Saci_2375 is an NADP+-dependent enzyme with the ability to function as ICDH, EC 1.1.1.42, and HICDH, EC 1.1.1.87

738195

NADPH

Sulfolobus acidocaldarius

Q4J6C9

Saci_2375 is an NADP+-dependent enzyme with the ability to function as ICDH, EC 1.1.1.42, and HICDH, EC 1.1.1.87

738195