1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version, for detailed information about D-lactate dehydrogenase, go to the full flat file.

Reaction

(R)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH1, D-LDH2, D-LDH3, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLDH, Fermentative lactate dehydrogenase, lactic acid dehydrogenase, LDH, Respiratory D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

Reference

Reference on EC 1.1.1.28 - D-lactate dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garvie, E.I.
Bacterial lactate dehydrogenases
Microbiol. Rev.
44
106-139
1980
Enterobacter aerogenes, Escherichia coli, Eubacterium limosum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus buchneri, Lactobacillus casei, Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. lactis, Lactobacillus fermentum, Lactobacillus jensenii, Lactobacillus jugurt-helveticus, Lactobacillus leichmannii, Lactobacillus plantarum, Lactobacillus vermiforme, Lactococcus lactis, Leuconostoc lactis, Leuconostoc mesenteroides, Leuconostoc mesenteroides subsp. cremoris, Leuconostoc mesenteroides subsp. dextranicum, Mammalia, Mycoplasma sp., Oenococcus oeni, Pediococcus acidilactici, Pediococcus damnosus, Pediococcus inopinatus, Pediococcus pentosaceus, Selenomonas ruminantium, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus sp., Staphylococcus warneri, Weissella confusa, Weissella paramesenteroides, Weissella viridescens
Manually annotated by BRENDA team
Jaenicke, R.; Muller, K.; Gde, G.
Dimeric lactic dehydrogenase from the bivalve mollusc Cardium edule
Naturwissenschaften
68
205-206
1981
Cardium edule
-
Manually annotated by BRENDA team
LeJohn, H.B.; Stevenson, R.M.
D(-)-lactate dehydrogenase from fungi
Methods Enzymol.
41B
293-298
1975
Phytophthora undulata, Pythium debaryanum, Sapromyces elongatus
Manually annotated by BRENDA team
Garland, R.C.; Kaplan, N.O.
Salt-induced alteration of D(-) lactate dehydrogenase from Polyspondylium pallidum
Biochem. Biophys. Res. Commun.
26
679-685
1967
Polysphondylium pallidum
Manually annotated by BRENDA team
Wolin, M.J.
Fructose-1,6-diphosphate requirement of streptococcal lactic dehydrogenases
Science
146
775-776
1964
Streptococcus equinus
Manually annotated by BRENDA team
Pascal, M.C.; Pichinoty, F.
Sur la configuration du lactate produit au cours de la fermentation du glucose par quelques enterobacteries
Ann. Inst. Pasteur (Paris)
107
55-62
1964
Enterobacter aerogenes
-
Manually annotated by BRENDA team
Storey, K.B.
Lactate dehydrogenase in tissue extracts of the land snail, Helix aspersa: unique adaptation of LDH subunits in a facultative anaerobe
Comp. Biochem. Physiol. B
56
181-187
1977
Helix aspersa
Manually annotated by BRENDA team
Long, G.L.; Ellington, W.R.; Duda, T.F.
Comparative enzymology and physiological role of D-lactate dehydrogenase from the foot muscle of two gastropod molluscs
J. Exp. Zool.
207
237-248
1979
Haliotis cracherodii, Helix aspersa
-
Manually annotated by BRENDA team
Wittenberger, C.L.
D(-)-Lactate dehydrogenase from butyribacterium rettgeri
Methods Enzymol.
41B
299-303
1975
Eubacterium limosum
Manually annotated by BRENDA team
Long, G.L.
D-Lactate dehydrogenase from the horseshoe crab
Methods Enzymol.
41B
313-323
1975
Limulus polyphemus
Manually annotated by BRENDA team
Long, G.L.; Kaplan, N.O.
Diphosphopyridine nucleotide-linked D-lactate dehydrogenases from the horseshoe crab, Limulus polyphemus and the seaworm, Nereis virens. I. Physical and chemical properties
Arch. Biochem. Biophys.
154
696-710
1973
Limulus polyphemus, Neanthes virens
Manually annotated by BRENDA team
Purohit, K.; Turian, G.
D(-)-lactate dehydrogenase from Allomyces. Partial purification and allosteric properties
Arch. Mikrobiol.
84
287-300
1972
Allomyces sp.
Manually annotated by BRENDA team
Le Bras, G.; Garel, J.R.
Properties of D-lactate dehydrogenase from Lactobacillus bulgaricus: a possible different evolutionary origin for the D- and L-lactate dehydrogenases
FEMS Microbiol. Lett.
79
89-93
1991
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Kochhar, S.; Hunziker, P.E.; Leong-Morgenthaler, P.; Hottinger, H.
Primary structure, physicochemical properties, and chemical modification of NAD+-dependent D-lactate dehydrogenase. Evidence for the presence of Arg-235, His-303, Tyr-101, and Trp-19 at or near the active site
J. Biol. Chem.
267
8499-8513
1992
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Kochhar, S.; Chuard, N.; Hottinger, H.
Cloning and overexpression of the Lactobacillus bulgaricus NAD(+)-dependent D-lactate dehydrogenase gene in Escherichia coli: purification and characterization of the recombinant enzyme
Biochem. Biophys. Res. Commun.
185
705-712
1992
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Erwin, A.L.; Gotschlich, E.C.
Oxidation of D-lactate and L-lactate by Neisseria meningitidis: Purification and cloning of meningococcal D-lactate dehydrogenase
J. Bacteriol.
175
6382-6391
1993
Neisseria meningitidis
Manually annotated by BRENDA team
Dartois, V.; Phalip, V.; Schmitt, P.; Divies, C.
Purification, properties and DNA sequence of the D-lactate dehydrogenase from Leuconostoc mesenteroides subsp. cremoris
Res. Microbiol.
146
291-302
1995
Leuconostoc mesenteroides subsp. cremoris, Leuconostoc mesenteroides subsp. cremoris (P51011)
Manually annotated by BRENDA team
Stoll, V.S.; Manohar, A.V.; Gillon, W.; MacFarlane, E.L.; Hynes, R.C.; Pai, E.F.
A thioredoxin fusion protein of VanH, a D-lactate dehydrogenase from Enterococcus faecium: cloning, expression, purification, kinetic analysis, and crystallization
Protein Sci.
7
1147-1155
1998
Enterococcus faecium
Manually annotated by BRENDA team
Kochhar, S.; Lamzin, V.S.; Razeto, A.; Delley, M.; Hottinger, H.; Germond, J.E.
Roles of His205, His296, His303 and Asp259 in catalysis by NAD+-specific D-lactate dehydrogenase
Eur. J. Biochem.
267
1633-1639
2000
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Dym, O.; Pratt, E.A.; Ho, C.; Eisenberg, D.
The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme
Proc. Natl. Acad. Sci. USA
97
9413-9418
2000
Escherichia coli, Escherichia coli (P06149)
Manually annotated by BRENDA team
Nessler, S.; Le Bras, G.; Le Bras, G.; Garel, J.R.
Crystallization of D-lactate dehydrogenase from Lactobacillus bulgaricus
J. Mol. Biol.
235
370-371
1994
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Kochhar, S.; Chuard, N.; Hottinger, H.
Glutamate 264 modulates the pH dependence of the NAD(+)-dependent D-lactate dehydrogenase
J. Biol. Chem.
267
20298-20301
1992
Lactobacillus delbrueckii subsp. bulgaricus
Manually annotated by BRENDA team
Hachiya, N.S.; Sakasegawa, Y.; Jozuka, A.; Tsukita, S.; Kaneko, K.
Interaction of D-lactate dehydrogenase protein 2 (Dld2p) with F-actin: implication for an alternative function of Dld2p
Biochem. Biophys. Res. Commun.
319
78-82
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Horikiri, S.; Aizawa, Y.; Kai, T.; Amachi, S.; Shinoyama, H.; Fujii, T.
Electron acquisition system constructed from an NAD-independent D-lactate dehydrogenase and cytochrome c2 in Rhodopseudomonas palustris No. 7
Biosci. Biotechnol. Biochem.
68
516-522
2004
Rhodopseudomonas palustris
Manually annotated by BRENDA team
Isobe, K.; Koide, Y.; Yokoe, M.; Wakao, N.
Crystallization and some properties of D-lactate dehydrogenase from Staphylococcus sp. LDH-1
J. Biosci. Bioeng.
94
330-335
2002
Staphylococcus sp., Staphylococcus sp. LDH-1
Manually annotated by BRENDA team
Iino, T.; Uchimura, T.; Komagata, K.
The effect of sodium acetate on the activity of L- and D-lactate dehydrogenases in Lactobacillus sakei NRIC 1071T and other lactic acid bacteria
J. Gen. Appl. Microbiol.
49
51-58
2003
Lactobacillus plantarum, Lactobacillus plantarum NRIC 1067T, Lactobacillus sakei, Lactobacillus sakei NRIC 1071T
Manually annotated by BRENDA team
Razeto, A.; Kochhar, S.; Hottinger, H.; Dauter, M.; Wilson, K.S.; Lamzin, V.S.
Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus
J. Mol. Biol.
318
109-119
2002
Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. bulgaricus (P26297)
Manually annotated by BRENDA team
Schmidt, E.; Ghisalba, O.; Gygax, D.; Sedelmeier, G.
Optimization of a process for the production of (R)-2-hydroxy-4-phenylbutyric acid - an intermediate for inhibitors of angiotonsin converting enzyme
J. Biotechnol.
24
315-327
1992
Staphylococcus epidermidis
Manually annotated by BRENDA team
Fujisawa, T.; Akagi, S.; Kawase, M.; Yamamoto, M.; Ohmori, S.
D-lactate metabolism in starved Octopus ocellatus
J. Exp. Zool. A
303A
489-496
2005
Octopus ocellatus
-
Manually annotated by BRENDA team
Minenko, A.N.; Luzikov, V.N.; Kovaleva, I.E.
Use of the addressing sequence of yeast D-lactate dehydrogenase for insertion of CYP11A1p into the inner membrane of yeast mitochondria
Biochemistry
71
32-38
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Findrik, Z.; Poljanac, M.; Vasic-Racki, D.
Modelling and optimization of the (R)-(+)-3,4-dihydroxyphenyllactic acid production catalyzed with D-lactate dehydrogenase from Lactobacillus leishmannii using genetic algorithm
Chem. Biochem. Eng. Q.
19
351-358
2005
Lactobacillus leichmannii
-
Manually annotated by BRENDA team
Ishikura, Y.; Tsuzuki, S.; Takahashi, O.; Tokuda, C.; Nakanishi, R.; Shinoda, T.; Taguchi, H.
Recognition site for the side chain of 2-ketoacid substrate in D-lactate dehydrogenase
J. Biochem.
138
741-749
2005
Lactobacillus pentosus
Manually annotated by BRENDA team
Shinoda, T.; Arai, K.; Shigematsu-Iida, M.; Ishikura, Y.; Tanaka, S.; Yamada, T.; Kimber, M.S.; Pai, E.F.; Fushinobu, S.; Taguchi, H.
Distinct conformation-mediated functions of an active site loop in the catalytic reactions of NAD-dependent D-lactate dehydrogenase and formate dehydrogenase
J. Biol. Chem.
280
17068-17075
2005
Lactobacillus pentosus
Manually annotated by BRENDA team
Ishida, N.; Suzuki, T.; Tokuhiro, K.; Nagamori, E.; Onishi, T.; Saitoh, S.; Kitamoto, K.; Takahashi, H.
D-lactic acid production by metabolically engineered Saccharomyces cerevisiae
J. Biosci. Bioeng.
101
172-177
2006
Leuconostoc mesenteroides (P51011)
Manually annotated by BRENDA team
Zhu, J.; Shimizu, K.
Effect of a single-gene knockout on the metabolic regulation in Escherichia coli for D-lactate production under microaerobic condition
Metab. Eng.
7
104-115
2005
Escherichia coli
Manually annotated by BRENDA team
Okino, S.; Suda, M.; Fujikura, K.; Inui, M.; Yukawa, H.
Production of D-lactic acid by Corynebacterium glutamicum under oxygen deprivation
Appl. Microbiol. Biotechnol.
78
449-454
2008
Escherichia coli, Lactobacillus delbrueckii
Manually annotated by BRENDA team
Mazzei, F.; Botre, F.; Favero, G.
Peroxidase based biosensors for the selective determination of D,L-lactic acid and L-malic acid in wines
Microchem. J.
87
81-86
2007
Staphylococcus epidermidis
-
Manually annotated by BRENDA team
Xu, T.T.; Bai, Z.Z.; Wang, L.J.; He, B.F.
Breeding of D(-)-lactic acid high producing strain by low-energy ion implantation and preliminary analysis of related metabolism
Appl. Biochem. Biotechnol.
160
314-321
2008
Sporolactobacillus sp., Sporolactobacillus sp. DX12
Manually annotated by BRENDA team
Okano, K.; Yoshida, S.; Yamada, R.; Tanaka, T.; Ogino, C.; Fukuda, H.; Kondo, A.
Improved production of homo-D-lactic acid via xylose fermentation by introduction of xylose assimilation genes and redirection of the phosphoketolase pathway to the pentose phosphate pathway in L-Lactate dehydrogenase gene-deficient Lactobacillus plantarum
Appl. Environ. Microbiol.
75
7858-7861
2009
Lactobacillus plantarum, Lactobacillus plantarum NCIMB 8826
Manually annotated by BRENDA team
Antonyuk, S.V.; Strange, R.W.; Ellis, M.J.; Bessho, Y.; Kuramitsu, S.; Inoue, Y.; Yokoyama, S.; Hasnain, S.S.
Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD+ and lactic acid (or pyruvate)
Acta Crystallogr. Sect. F
65
1209-1213
2009
Aquifex aeolicus, Aquifex aeolicus (O66939)
Manually annotated by BRENDA team
Shibahara, T.; Satomura, T.; Kawakami, R.; Ohshima, T.; Sakuraba, H.
Crystallization and preliminary X-ray analysis of a dye-linked D-lactate dehydrogenase from the aerobic hyperthermophilic archaeon Aeropyrum pernix
Acta Crystallogr. Sect. F
67
1425-1427
2011
Aeropyrum pernix (Q9YEU4)
Manually annotated by BRENDA team
Yu, S.; Jiang, H.; Jiang, B.; Mu, W.
Characterization of D-lactate dehydrogenase producing D-3-phenyllactic acid from Pediococcus pentosaceus
Biosci. Biotechnol. Biochem.
76
853-855
2012
Pediococcus pentosaceus, Pediococcus pentosaceus ATCC 25745
Manually annotated by BRENDA team
Mu, W.; Yu, S.; Jiang, B.; Li, X.
Characterization of D-lactate dehydrogenase from Pediococcus acidilactici that converts phenylpyruvic acid into phenyllactic acid
Biotechnol. Lett.
34
907-911
2012
Pediococcus acidilactici, Pediococcus acidilactici DSM 20284
Manually annotated by BRENDA team
Li, L.; Eom, H.J.; Park, J.M.; Seo, E.; Ahn, J.E.; Kim, T.J.; Kim, J.H.; Han, N.S.
Characterization of the major dehydrogenase related to D-lactic acid synthesis in Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
Enzyme Microb. Technol.
51
274-279
2012
Leuconostoc mesenteroides subsp. mesenteroides, Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
Manually annotated by BRENDA team
Wienstroer, J.; Engqvist, M.K.; Kunz, H.H.; Fluegge, U.I.; Maurino, V.G.
D-Lactate dehydrogenase as a marker gene allows positive selection of transgenic plants
FEBS Lett.
586
36-40
2012
Arabidopsis thaliana, Arabidopsis thaliana Columbia-0
Manually annotated by BRENDA team
Jun, C.; Sa, Y.; Gu, S.; Joo, J.; Kim, S.; Kim, K.; Kim, Y.
Discovery and characterization of a thermostable D-lactate dehydrogenase from Lactobacillus jensenii through genome mining
Process Biochem.
48
109-117
2013
Lactobacillus jensenii
-
Manually annotated by BRENDA team