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1.1.1.270: 3beta-hydroxysteroid 3-dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid 3-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.270

Reaction

a 3beta-hydroxysteroid
+
NADP+
=
a 3-oxosteroid
+
NADPH
+
H+

Synonyms

17beta-HSD7, 17beta-hydroxysteroid dehydrogenase type 7, 3-keto reducing enzyme, 3-keto reductase, 3-keto-reductase, 3-ketoreductase, 3-ketosteroid reductase, 3-KSR, 3-oxo steroid reductase, 3-oxosteroid reductase, 3beta-HSD, 3beta-HSD1, 3beta-HSD2, 3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 2, 3beta-hydroxysteroid dehydrogenase/isomerase, AKR1C1, AKR1C2, AKR1Cs, aldo-keto reductase 1C2, CDD59473, Erg27, Erg27p, Hsd17, HSD17B7, HSD3B1, reductase, 3-oxo steroid, reductive 3beta-HSD, SDR11E1, SDR11E2, steroid-3-ketoreductase, sterol 3-ketoreductase, sterone-reducing enzyme, type 3 3alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000008
(Z)-2-(4-methoxyphenylimino)-7-hydroxy-N-(pyridin-2-yl)-2H-chromene-3-carboxamide
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.00006
3-(4-hydroxy-2-methoxyphenyl)acrylic acid 3-(3-hydroxyphenyl)propyl ester
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.0017
AL1567
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.0006
bisdemethoxycurcumin
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.0028
diethylstilbestrol
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.26
Diphenic acid
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.0015
epalrestat
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.000043
minalrestat
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.0004
oleanolic acid
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.0015
quercetin
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.0053
sorbinil
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.00086
sulindac
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.00016
Tolrestat
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme
0.00023
trilostane
Rattus norvegicus
-
IC50: 0.00023 mM
0.0012
zopolrestat
Oryctolagus cuniculus
-
pH 7.4, 25°C, wild-type enzyme