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1.1.1.268: 2-(R)-hydroxypropyl-CoM dehydrogenase

This is an abbreviated version!
For detailed information about 2-(R)-hydroxypropyl-CoM dehydrogenase, go to the full flat file.

Reaction

2-(R)-hydroxypropyl-CoM
+
NAD+
=
2-oxopropyl-CoM
+
NADH
+
H+

Synonyms

(R)-hydroxypropyl-coenzyme M dehydrogenase, (R)-hydroxypropylthioethanesulfonate dehydrogenase, 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase, 2-(R)-hydroxypropyl-coenzyme M dehydrogenase, R-HPCDH, xecD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.268 2-(R)-hydroxypropyl-CoM dehydrogenase

KI Value

KI Value on EC 1.1.1.268 - 2-(R)-hydroxypropyl-CoM dehydrogenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.156
(2S)-2-hydroxypropyl-CoM
pH and temperature not specified in the publication, versus (2R)-2-hydroxypropyl-CoM
0.406
2-(2-methyl-2-hydroxypropylthio)-ethanesulfonate
pH and temperature not specified in the publication, versus (2R)-2-hydroxypropyl-CoM
-
0.29 - 0.406
2-(2-methyl-2-hydroxypropylthio)ethanesulfonate
0.156
2-(S)-hydroxypropyl-CoM
-
competitive inhibition with respect to 2-(R)-hydroxypropyl-CoM
1.2
2-bromoethanesulfonate
pH 7.4, 30°C
2.25 - 3.62
CoM
26.7
ethanesulfonate
-
mixed-type inhibition with respect to 2-(R)-hydroxypropyl-CoM
2.25
mercaptoethanesulfonate
-
mixed-type inhibition with respect to 2-(R)-hydroxypropyl-CoM
147.8
methanesulfonate
-
mixed-type inhibition with respect to 2-(R)-hydroxypropyl-CoM