1.1.1.262: 4-hydroxythreonine-4-phosphate dehydrogenase
This is an abbreviated version!
For detailed information about 4-hydroxythreonine-4-phosphate dehydrogenase, go to the full flat file.
Reaction
Synonyms
4-(phosphohydroxy)-L-threonine dehydrogenase, L-threonine 4-phosphate dehydrogenase, NAD-dependent threonine 4-phosphate dehydrogenase, PdxA
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.262 - 4-hydroxythreonine-4-phosphate dehydrogenase
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REACTION DIAGRAM
4-(phosphohydroxy)-L-threonine + NAD+
3-phosphohydroxy-1aminoacetone + CO2 + NADH + H+
-
involved in pyridoxal 5'-phosphate formation
further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate
r
4-(phosphonooxy)threonine + NAD(P)+
2-amino-3-oxo-4-phosphonooxybutyrate + NAD(P)H
fourth step of the pyridoxal 5'-phosphate biosynthesis
-
-
?
4-(phosphonooxy)threonine + NAD(P)+
3-amino-1-hydroxyacetone 1-phosphate + CO2 + NAD(P)H
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involved in the biosynthesis of vitamin B6
-
-
?
2-amino-3-oxo-4-phosphohydroxybutyrate + NADH
-
involved in pyridoxal 5'-phosphate formation
further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate
r
4-(phosphohydroxy)-L-threonine + NAD+
2-amino-3-oxo-4-phosphohydroxybutyrate + NADH
-
involved in pyridoxal 5'-phosphate formation
undergoes decarboxylation either catalysed by the enzyme or after release, further formation of pyridoxal 5'-phosphate catalysed by PdxJ protein
r