1.1.1.26: glyoxylate reductase

This is an abbreviated version, for detailed information about glyoxylate reductase, go to the full flat file.

Reaction

glycolate
+
NAD+
=
glyoxylate
+
NADH
+
H+

Synonyms

GHPR, glycolate oxidase, glyoxylate reductase isoform 1, glyoxylate/hydroxypyruvate reductase, glyoxylic acid reductase, GLYR1, GLYR2, GxrA, NADH-dependent glyoxylate reductase, NADH-glyoxylate reductase, reductase, glyoxylate, SSO3187, succinic semialdehyde/glyoxylate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.26 glyoxylate reductase

Substrates Products

Substrates Products on EC 1.1.1.26 - glyoxylate reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxobutyrate + NADH
isovalerate + NAD+
show the reaction diagram
-
GxrA
-
-
?
glycolate + NAD+
glyoxylate + NADH
show the reaction diagram
glycolate + NAD+
glyoxylate + NADH + H+
show the reaction diagram
glycolate + NADP+
glyoxylate + NADPH + H+
show the reaction diagram
-
-
-
r
glyoxylate + NADH
glycolate + NAD+
show the reaction diagram
glyoxylate + NADH + H+
glycolate + NAD+
show the reaction diagram
glyoxylate + NADPH
glycolate + NADP+
show the reaction diagram
-
a recombinant gamma hydroxybutyrate dehydrogenase, EC 1.1.1.61, exhibits high glyoxylate reductase activity with a 250fold higher preference for glyoxylate than with succinic semialdehyde, via an essentially irreversible, NADPH-based mechanism, overview
-
-
ir
glyoxylate + NADPH + H+
glycolate + NADP+
show the reaction diagram
hydroxypyruvate + NADH
D-glycerate + NAD+
show the reaction diagram
hydroxypyruvate + NADH + H+
D-glycerate + NAD+
show the reaction diagram
phenylpyruvate + NADH
phenyllactate + NAD+
show the reaction diagram
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
show the reaction diagram
-
succinic semialdehyde-dependent GLYR activity potentially occurs in planta, despite the fact that glyoxylate is the preferred substrate in vitro
-
-
ir
additional information
?
-