1.1.1.26: glyoxylate reductase
This is an abbreviated version!
For detailed information about glyoxylate reductase, go to the full flat file.
Word Map on EC 1.1.1.26
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1.1.1.26
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hyperoxalurias
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oxalate
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ph2
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stone
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nephrolithiasis
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nephrocalcinosis
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l-glycerate
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photorespiratory
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alanine:glyoxylate
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urolithiasis
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4-hydroxy-2-oxoglutarate
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glyrs
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diagnostics
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medicine
- 1.1.1.26
- hyperoxalurias
- oxalate
- ph2
- stone
- nephrolithiasis
- nephrocalcinosis
- l-glycerate
-
photorespiratory
-
alanine:glyoxylate
-
urolithiasis
- 4-hydroxy-2-oxoglutarate
- glyrs
- diagnostics
- medicine
Reaction
Synonyms
GHPR, glycerate dehydrogenase, glycolate oxidase, glyoxylate reductase isoform 1, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate/hydroxypyruvate reductase, glyoxylic acid reductase, GLYR1, GLYR2, GRHPR, GxrA, HPR1, NADH-dependent glyoxylate reductase, NADH-glyoxylate reductase, reductase, glyoxylate, SSO3187, succinic semialdehyde/glyoxylate reductase
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.26 - glyoxylate reductase
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REACTION DIAGRAM
succinic semialdehyde + NADPH + H+
4-hydroxybutyrate + NADP+
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succinic semialdehyde-dependent GLYR activity potentially occurs in planta, despite the fact that glyoxylate is the preferred substrate in vitro
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ir
hydroxypyruvate + NADH
D-glycerate + NAD+
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located exclusively in the peroxisomes, prefers NAD+/NADH
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r
hydroxypyruvate + NADH
D-glycerate + NAD+
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located exclusively in the peroxisomes, prefers NAD+/NADH
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r
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both cytosolic GLYR1 and plastidial GLYR2 catalyse the essentially irreversible, NADPH-based conversion of glyoxylate into glycolate, and can be regulated by the NADPH/NADP ratio
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additional information
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the recombinant AtHPR1 prefers prefers NADH over NADPH and hydroxypyruvate over glyoxylate. Isozyme AtHPR1 also converts glyoxylate to glycolate, albeit with much lower catalytic efficiency than for hydroxypyruvate
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additional information
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in the endosymbiont, a 3-phosphoglycerate dehydrogenase exhibits glyoxylate/hydroxypyruvate reductase activity, substrate specificity, overview
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additional information
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in the endosymbiont, a 3-phosphoglycerate dehydrogenase exhibits glyoxylate/hydroxypyruvate reductase activity, substrate specificity, overview
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