1.1.1.26: glyoxylate reductase

This is an abbreviated version, for detailed information about glyoxylate reductase, go to the full flat file.

Reaction

glycolate
+
NAD+
=
glyoxylate
+
NADH
+
H+

Synonyms

GHPR, glycerate dehydrogenase, glycolate oxidase, glyoxylate reductase isoform 1, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate/hydroxypyruvate reductase, glyoxylic acid reductase, GLYR1, GLYR2, GRHPR, GxrA, HPR1, NADH-dependent glyoxylate reductase, NADH-glyoxylate reductase, reductase, glyoxylate, SSO3187, succinic semialdehyde/glyoxylate reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.26 glyoxylate reductase

Disease

Disease on EC 1.1.1.26 - glyoxylate reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma, Hepatocellular
Glyoxylate Reductase/Hydroxypyruvate Reductase: A Novel Prognostic Marker for Hepatocellular Carcinoma Patients after Curative Resection.
Colitis
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
Congenital Hyperinsulinism
Glycolate oxidase deficiency in a patient with congenital hyperinsulinism and unexplained hyperoxaluria.
Crohn Disease
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
Dehydration
Nitrogen Metabolism in Adaptation of Photosynthesis to Water Stress in Rice Grown under Different Nitrogen Levels.
Genetic Diseases, Inborn
A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5'UTR causing primary hyperoxaluria type II.
glyoxylate reductase deficiency
Combined Liver-Kidney Transplantation for Primary Hyperoxaluria Type 2: A Case Report.
Glycolate oxidase deficiency in a patient with congenital hyperinsulinism and unexplained hyperoxaluria.
Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2.
Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism.
[Primary hiperoxaluria: a new mutation in gen AGXT (R197Q) cause of neonatal convulsions]
Hyperoxaluria
Effect of Tribulus terrestris on oxalate metabolism in rats.
Failure of isolated kidney transplantation in a pediatric patient with primary hyperoxaluria type 2.
Glycolate oxidase deficiency in a patient with congenital hyperinsulinism and unexplained hyperoxaluria.
Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis.
Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.
The molecular basis of kidney stones.
[Primary hiperoxaluria: a new mutation in gen AGXT (R197Q) cause of neonatal convulsions]
Hyperoxaluria, Primary
4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition.
A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5'UTR causing primary hyperoxaluria type II.
A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2.
An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.
Biochemical and genetic diagnosis of the primary hyperoxalurias: a review.
Combined Liver-Kidney Transplantation for Primary Hyperoxaluria Type 2: A Case Report.
Enzymological characterization of a feline analogue of primary hyperoxaluria type 2: a model for the human disease.
Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2.
Evaluation of mutation screening as a first line test for the diagnosis of the primary hyperoxalurias.
Glycolate Oxidase Is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I.
Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2.
High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design.
Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2).
Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.
Kinetic analysis and tissue distribution of human D-glycerate dehydrogenase/glyoxylate reductase and its relevance to the diagnosis of primary hyperoxaluria type 2.
Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling.
Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
Modification of primers for GRHPR genotyping: avoiding allele dropout by single nucleotide polymorphisms and homology sequence.
Molecular analysis of the glyoxylate reductase (GRHPR) gene and description of mutations underlying primary hyperoxaluria type 2.
Novel mutation in the GRHPR gene in a Chinese patient with primary hyperoxaluria type 2 requiring renal transplantation from a living related donor.
Phenotypic and functional analysis of human SLC26A6 variants in patients with familial hyperoxaluria and calcium oxalate nephrolithiasis.
Primary cultures of renal proximal tubule cells derived from individuals with primary hyperoxaluria.
Primary hyperoxaluria type 2: enzymology.
Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha.
Re: Glycolate Oxidase is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I.
Recent developments in our understanding of primary hyperoxaluria type 2.
Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism.
Tissue differences in the expression of mutations and polymorphisms in the GRHPR gene and implications for diagnosis of primary hyperoxaluria type 2.
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
Kidney Calculi
Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design.
Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling.
Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha.
Purification and characterization of recombinant human liver glycolate oxidase.
Kidney Failure, Chronic
Failure of isolated kidney transplantation in a pediatric patient with primary hyperoxaluria type 2.
Metabolic Diseases
Restrictive cardiomyopathy in a patient with primary hyperoxaluria type II.
Metabolism, Inborn Errors
Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism.
Neoplasms
Candidate driver genes in microsatellite-unstable colorectal cancer.
Glyoxylate Reductase/Hydroxypyruvate Reductase: A Novel Prognostic Marker for Hepatocellular Carcinoma Patients after Curative Resection.
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
Nephrocalcinosis
Hydroxyproline metabolism in mouse models of primary hyperoxaluria.
Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling.
Obesity
Differential representation of liver proteins in obese human subjects suggests novel biomarkers and promising targets for drug development in obesity.
Renal Insufficiency
Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling.
Urolithiasis
Experimental urolithiasis : Part II--a comparative kinetic study of glyoxalase I, glycolate oxidase, alkaline phosphatase & lactate dehydrogenase in the normal rat kidney & bladder & its alterations in urolithiasis.
Vitamin B 6 Deficiency
Vitamin B6 deficiency as related to oxalate-synthesizing enzymes in growing rats.