1.1.1.255: mannitol dehydrogenase

This is an abbreviated version, for detailed information about mannitol dehydrogenase, go to the full flat file.

Reaction

D-mannitol
+
NAD+
=
D-mannose
+
NADH
+
H+

Synonyms

mannitol 1-dehydrogenase, mannitol 1-oxidoreductase, mannitol:mannose 1-oxidoreductase, MTD, NAD-dependent mannitol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.255 mannitol dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.255 - mannitol dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
dose dependent decrease in enzyme activity
1,4-dithioerythritol
-
1.09 mM, 50% inhibition, partially reversed by diamide
1,4-dithiothreitol
-
0.57 mM, 50% inhibition, reversed by diamide
2-mercaptoethanol
-
30 mM, 50% inhibition, partially reversed by diamide
AMP
-
Ki: 0.50-0.80 mM at pH 9.5, Ki = 0.64 mM at pH 7.0
ATP
-
Ki: 1.10 mM at pH 7.0
D-mannose
-
competitive inhibition, Ki: 200 mM
D-threose
-
competitive inhibition, Ki: 18 mM
NADH
-
strong inhibition at 0.1 mM
additional information
-
EDTA and EGTA did not affect enzyme activity
-